Journal of Industrial and Engineering Chemistry, Vol.112, 210-217, August, 2022
    DOI 10.1016/j.jiec.2022.05.015  Export Citation
    Iron Single-Atom nanocatalysts in response to tumor microenvironment for highly efficient Chemo-chemodynamic therapy
    Tushuai Li 1, 2 , Li Chen 3 , Xiao Fu 4 , Zhihong Liu 3 , Shenglong Zhu 1, 2 , Yongquan Chen 1, 2 , and Jie Zhang 5, †
    • 1 Wuxi School of Medicine, Jiangnan University, Wuxi 214013, China
    • 2 Jiangsu Translational Medicine Research Institute Wuxi Branch, Wuxi Translational Medicine Research Center, Wuxi 214013, China
    • 3 The State Key Laboratory of Pharmaceutical Biotechnology, Medical School, School of Life Sciences, Nanjing University, Nanjing 210033, China
    • 4 Department of General Surgery, Institute of Translational Medicine, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China
    • 5 School of Biology and Food Engineering, Changshu Institute of Technology, Suzhou 215500, PR China
    E-mail:
    Chemodynamic therapy (CDT) based on multifunctional nanoparticles (NPs) has occurred as an attractive cancer treatment that covers the shortage of nonnegligible limitations from single therapy. Herein, we synthesize a safe and universal CDT nanoparticle—iron single-atom nanoparticle (Fe SANP), in which Fe single-atom as the active catalytic site is anchored in a carbon framework with encapsulated doxorubicin (DOX). Fe SANPs work as catalase-like nanozyme for hydroxyl radicals (●OH) production. The prepared NPs (denoted as DOX@Fe SANPs) can efficiently mediate peroxidase-like activity with the existence of H2O2 that enhances cancer cell elimination by generating abundant ●OH. DOX@Fe SANPs exhibit a pHinduced degradable character that contributes to specific drug release in the tumor microenvironment (TME). DOX@Fe SANPs produce ignorable systematic toxicity after biodegradation and drug delivery processes. Collectively, this study highlights the efficient anti-tumor performances of the iron single-atom nanocatalysts containing an anti-cancer drug DOX.
    Keywords: Chemodynamic therapy ; Fe single-atom nanoparticles ; Hydroxyl radicals ; Anti-tumor
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