| 학회 | 한국공업화학회 |
| 학술대회 | 2019년 봄 (05/01 ~ 05/03, 부산 벡스코(BEXCO)) |
| 권호 | 23권 1호 |
| 발표분야 | 생체재료_포스터 |
| 제목 | Preparation of protein drug immobilization materials using UV curable gelatin derivatives |
| 초록 | Protein drugs can't remain in the affected sites during treatment because of its short half life, and also difficult to achieve effect because of degradation caused by enzymes. Photo-immobilization techniques can be used to immobilize protein drugs in the body and to maintain the drug constantly. The drug immobilization material is a natural polymer that should have biocompatibility, biodegradability and low toxicity. In the food industry and drug delivery, gelatin has been selected for this study as a harmless substance and suitable for immobilizing protein drugs. 1H-NMR and FT-IR spectroscopy were demonstrated that azido group was introduced into Gelatin. In addition, cell proliferation experiments confirmed whether the immobilized protein drug had a lasting effect and was harmless in the body. The ability to immobilize drug was confirmed by fluorescent protein using fluorescence microscope. Based on these characteristics, Az-Gelatin is expected to be application in medical field. |
| 저자 | 이태훈 , 김신웅 , 손태일 |
| 소속 | 중앙대 |
| 키워드 | Gelatin ; Photo-immobilization techniques ; Azido group ; Az-Gelatin |
