| 학회 | 한국공업화학회 |
| 학술대회 | 2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 | 24권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Tumor microenvironment and lysosome pH-sensitive carbon-Dots for cancer therapy |
| 초록 | pH-sensitive polymers are used for many applications such as drug delivery, gene delivery, especially, cancer treatment. Because tumor microenvironment (TME) and lysosome have each acidic pH 6.8 and pH 5.5 unlike normal cells (pH 7.2 ~7.4). But, pH-sensitive polymers have some demerits such as certainly necessary synthesis, wide distribution of molecular weight, difficult to regulate toxicity and biodegradation, drug loading efficiency and release rate. C-Dots are composed organic materials containing carbon. C-Dots have many advantages that fluorescence, low cost, excellent biocompatibility easy synthesis such as hydrothermal, microwave, etc. We develop TME and lysosome pH-sensitive C-Dots (TLpSC) through microwave method. Drug release in TLpSC are higher than in control group at TME. In vitro, we confirmed the therapeutic effect using various cancer cell lines. In vivo, we confirmed the tumor treatment ability of drug loading TLpSC using tumor bearing mouse. |
| 저자 | 이장수 , 서정덕 , 이종환 , 이채빈 , 배수경 , 나건 |
| 소속 | 가톨릭대 |
| 키워드 | carbon dot ; cancer therapy |
