| 학회 | 한국고분자학회 |
| 학술대회 | 2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 | 46권 2호 |
| 발표분야 | 대학원생 구두발표(영어발표, 발표15분) |
| 제목 | Redox -Sensitive Polyglycerol Nanogels Stimulate the Photo-Responsive Cytotoxicity of a Ir(III) Complex |
| 초록 | Tumor microenvironment involves more vigorous redox signaling than normal cells, which has led to the development of cancer-specific degradable nanocarriers for cytotoxic anticancer drugs. Herein, we considerably improved the cancer-specific cytotoxicity of iridium complex-based photosensitizer (TIr3) by enhancing degradation sensitivity of nanogel (IrNG) through disrupting its disulfide bonds, reflecting the irreversible oxidation of intracellular glutathione by reactive oxygen species (ROS). The encapsulated TIr3 generates excessive ROS upon exposure to extremely weak light (0.25 J/cm2), efficiently degrading IrNG. The released cytotoxic TIr3 induces cancer cell apoptosis in in-vitro and in-vivo experiments. In contrast, IrNG shows high biocompatibility in the dark, even when exposed to high glutathione levels. This photosensitizer-produced ROS-mediated irreversible breakdown of IrNG provides new insight for designing unexplored cytotoxic photosensitizer-customized nanocarriers. |
| 저자 | 이채규 1 , 김병수 2 , 권태혁 1 |
| 소속 | 1 울산과학기술원, 2 연세대 |
| 키워드 | Cytotoxicity ; Drug delivery ; Nanoparticles ; Photooxidation ; Redox chemistry. |
