| 학회 | 한국고분자학회 |
| 학술대회 | 2022년 가을 (10/05 ~ 10/07, 대구컨벤션센터) |
| 권호 | 47권 2호 |
| 발표분야 | 기능성 고분자 |
| 제목 | An Injectable Anti-inflammatory Hyaluronic Acid Hydrogel with Decellularized Brain ECM and TI-EVs using Neural progenitor cells for Spinal cord Regeneration |
| 초록 | Traumatic spinal cord injury (SCI) is a serious condition that can cause permanent motor dysfunction including neurological dysfunctions and pain. In this study, we fabricated a hyaluronic acid (HA)-based hydrogel combined with decellularized brain matrix (DBM), polydeoxyribonucleotide (PDRN), TNF-α/IFN-γ primed mesenchymal stem cell-derived extracellular vesicles (TI-EV), and human neural progenitor cells (NPCs). This hydrogel (DBM/PDRN/TI-EV/NPC in HA gel) could supply structural support to nerves, and we predicted that nerve regeneration would be possible due to the synergistic effects of the included substances. The results showed that the hydrogel enhanced the proliferation and differentiation of NPCs in vitro. Functional motor recovery was also confirmed to be possible by reducing the inflammatory response and forming neurons and oligodendrocytes in vivo animal tests. This new bioactive injectable HA-based hydrogel is an effective candidate for SCI regeneration. |
| 저자 | 박소연 1 , 김다슬 1 , 김준혁 1 , 노은지 1 , 한인보 2 , 한동근 1 |
| 소속 | 1 차의과학대, 2 분당차병원 |
| 키워드 | Spinal cord injury ; Hyaluronic acid-based hydrogel ; Decellularized Brain ECM ; PDRN ; Neural progenitor cells |
