| 학회 | 한국화학공학회 |
| 학술대회 | 2021년 봄 (04/21 ~ 04/23, 부산 BEXCO) |
| 권호 | 27권 1호, p.452 |
| 발표분야 | 생물화공 |
| 제목 | PD-1-decorated nanocages with tumor draining lymph node targeting for anti-cancer immunotherapy |
| 초록 | Targeted delivery of an immunomodulatory molecule to the lymph nodes is an attractive approach to improve anti-cancer immunotherapeutic efficacy. In this study, to improve the therapeutic efficacy of the PD-1 blockade-based therapy, we designed nanocages by surface engineering to decorate a programmed cell death protein 1 (PD-1) that is capable of binding against programmed death-ligand 1 and 2 (PD-Ls). This nanocage-mediated multivalent interaction remarkably raises the binding avidity and improves the antagonistic activity, compared to soluble PD-1. Also, upon the desirable size of the nanocages for an optimal tumor-draining lymph node (TDLN)-targeting, we observed rapid draining and an increased accumulation into the TDLNs. Moreover, the interfering of PD-1/PD-Ls axis with the ultra-high affinity in the tumor microenvironment (effector phase) and the TDLNs (cognitive phase) significantly enhance the dendritic cell-mediated tumor-specific T cell activations. As a result, this successfully inhibits the tumor growth and induces complete tumor eradication in some mice. so, The delivery of immunomodulatory molecules with nanocages can be a efficient strategy to anti-tumor immunity. |
| 저자 | 성효동 1 , 이은정 1 , 김기범 2 , 남기훈 2 , 김인산 2 , 김나연 1 |
| 소속 | 1 경북대, 2 한국과학기술(연) |
| 키워드 | 생물화학공학 |
| VOD | VOD 보기 |
| 원문파일 | 초록 보기 |
