H Robert Frost, PhD
Title(s)
Associate Professor of Biomedical Data Science
Associate Professor of Molecular and Systems Biology
Additional Titles/Positions/Affiliations Associate Director of Quantitative Biomedical Sciences Graduate Program
Department(s)
Biomedical Data Science
Molecular and Systems Biology
Education
Dartmouth College, Ph.D., 2014Stanford University, MS, 1995
Stanford University, BS, 1993
Programs
Molecular and Cellular Biology Graduate Programs
Dartmouth Cancer Center
Quantitative Biomedical Sciences
Websites
https:
Academic Analytics View Profile
Contact Information
HB 7936Hanover NH 03755
Office: Rubin 704
Email: Hildreth.R.Frost@Dartmouth.edu
Professional Interests
My research focuses on the development of bioinformatics and biostatistics methods for analyzing high-dimensional genomic data. Areas of statistical interest include dimensionality reduction (e.g., PCA), hypothesis aggregation (e.g., gene set testing), and penalized estimation (e.g., LASSO penalized regression). Areas of biological interest include cell signaling, tissue-specific gene activity, tumor immunology, and cancer prognosis prediction.
Grant Information
NIH grants R35GM146586 and R21CA253408
Courses Taught
QBS 120: Foundations of Biostatistics I, Statistical Theory for the Quantitative Biomedical Sciences
A highly sensitive 3base™ assay for detecting Streptococcus pyogenes in saliva during controlled human pharyngitis.
Indraratna AD, Mytton S, Ricafrente A, Millar D, Gorman J, Azzopardi KI, Frost HR, Osowicki J, Steer AC, Skropeta D, Sanderson-Smith MLTalanta. 2024 May 6;276:126221. doi: 10.1016/j.talanta.2024.126221. Epub 2024 May 6.
PMID: 38776768
A generalized eigenvector centrality for multilayer networks with inter-layer constraints on adjacent node importance.
Frost HRAppl Netw Sci. 2024;9(1):14. doi: 10.1007/s41109-024-00620-8. Epub 2024 Apr 30.
PMID: 38699246
Identifying tumor type and cell type-specific gene expression alterations in pediatric central nervous system tumors.
Lee MK, Azizgolshani N, Shapiro JA, Nguyen LN, Kolling FW, Zanazzi GJ, Frost HR, Christensen BCNat Commun. 2024 Apr 30;15(1):3634. doi: 10.1038/s41467-024-47712-8. Epub 2024 Apr 30.
PMID: 38688897
Reconstruction Set Test (RESET): A computationally efficient method for single sample gene set testing based on randomized reduced rank reconstruction error.
Frost HRPLoS Comput Biol. 2024 Apr;20(4):e1012084. doi: 10.1371/journal.pcbi.1012084. Epub 2024 Apr 29.
PMID: 38683883
Tissue-adjusted pathway analysis of cancer (TPAC): A novel approach for quantifying tumor-specific gene set dysregulation relative to normal tissue.
Frost HRPLoS Comput Biol. 2024 Jan;20(1):e1011717. doi: 10.1371/journal.pcbi.1011717. Epub 2024 Jan 11.
PMID: 38206988
Molecular characterization of the interaction between human IgG and the M-related proteins from Streptococcus pyogenes.
Proctor EJ, Frost HR, Satapathy S, Botquin G, Urbaniec J, Gorman J, De Oliveira DMP, McArthur J, Davies MR, Botteaux A, Smeesters P, Sanderson-Smith MJ Biol Chem. 2024 Feb;300(2):105623. doi: 10.1016/j.jbc.2023.105623. Epub 2024 Jan 3.
PMID: 38176650
Cell type-specific interaction analysis using doublets in scRNA-seq.
Schiebout C, Lust H, Huang Y, Frost HRBioinform Adv. 2023;3(1):vbad120. doi: 10.1093/bioadv/vbad120. Epub 2023 Sep 6.
PMID: 37745004
STREAK: A supervised cell surface receptor abundance estimation strategy for single cell RNA-sequencing data using feature selection and thresholded gene set scoring.
Javaid A, Frost HRPLoS Comput Biol. 2023 Aug;19(8):e1011413. doi: 10.1371/journal.pcbi.1011413. Epub 2023 Aug 21.
PMID: 37603589
Characterizing control of memory CD8 T cell differentiation by BTB-ZF transcription factor Zbtb20.
Preiss NK, Kamal Y, Wilkins OM, Li C, Kolling FW 4th, Trask HW, Usherwood YK, Cheng C, Frost HR, Usherwood EJLife Sci Alliance. 2023 Sep;6(9) doi: 10.26508/lsa.202201683. Epub 2023 Jul 6.
PMID: 37414528
SPECK: an unsupervised learning approach for cell surface receptor abundance estimation for single-cell RNA-sequencing data.
Javaid A, Frost HRBioinform Adv. 2023;3(1):vbad073. doi: 10.1093/bioadv/vbad073. Epub 2023 Jun 13.
PMID: 37359727
