Lucas A Salas, MD, MPH, PhD
Title(s) Assistant Professor of Epidemiology
Additional Titles/Positions/Affiliations
Investigator Cancer Population Sciences Research Program, Dartmouth Hitchcock- Norris Cotton Cancer Center
Department(s)
Epidemiology
Education
Universitat Pompeu Fabra, PhD 2015
Universitat Pompeu Fabra, MPH 2011
Universidad de Antioquia, Epidemiology 2007
Universidad Nacional de Colombia, MD 2001
Programs
Quantitative Biomedical Sciences
Other
NIH Biosketch Salas_L_BIO_2020-09-21.pdf
Websites
https:
https:
https:
https:
https:
https:
Academic Analytics View Profile
Contact Information
Email: Lucas.A.Salas@Dartmouth.edu
Professional Interests
The broad goal of Dr. Salas research is to investigate how cell heterogeneity impacts human health and disease, with an emphasis on how genetic, environmental, and lifestyle factors model the human epigenome and therefore the cell plasticity. Dr. Salas’ laboratory studies how some key epigenetic mechanisms (DNA methylation, DNA hydroxymethylation, and miRNA alterations) affect gene expression and cancer outcomes, including how the immune cells are altered in this disease. Other research interests include biomarker development, chronic inflammation, and human disease, and how exposures during fetal life alter newborn and childhood outcomes.
Grant Information
W81XWH-20-1-0778, Congressionally Directed Medical Research Programs/Department of Defense
Salas Diaz, Lucas A (PI) 09/01/20-08/31/24
Epigenetic modifications of cytosines in clear cell kidney carcinogenesis and survival
P20 GM104416-09/8299, National Institute of General Medical Sciences
Salas Diaz, Lucas A (PI) 10/01/20-01/01/23
A single-cell approach to disentangle tumor microenvironments in short and long survivors to clear cell renal carcinoma
Courses Taught
QBS.132
CANB.103
MDED.118
QBS.271
PEMM.212
Mentoring Information
Current trainees:
Ze Zhang, QBS
Steven Pike, IND
Prasoona Karra, Ph.D. (postdoctoral fellow)
Chinaza Nnam, MCB (rotation student)
Immunomethylomic profiles of long-term head and neck squamous cell carcinoma survivors on immune checkpoint inhibitors.
Lee MK, Zhang Z, Sehgal K, Butler R, Stolrow H, Ramush G, Shirai K, Koestler DC, Salas LA, Wiencke JK, Haddad R, Kelsey KT, Christensen BCEpigenomics. 2024 May 21;:1-9. doi: 10.1080/17501911.2024.2343274. Epub 2024 May 21.
PMID: 38869472
Molecular subtypes of high-grade serous ovarian cancer across racial groups and gene expression platforms.
Davidson NR, Barnard ME, Hippen AA, Campbell A, Johnson CE, Way GP, Dalley BK, Berchuck A, Salas LA, Peres LC, Marks JR, Schildkraut JM, Greene CS, Doherty JACancer Epidemiol Biomarkers Prev. 2024 May 23; doi: 10.1158/1055-9965.EPI-24-0113. Epub 2024 May 23.
PMID: 38780898
Associations in cell type-specific hydroxymethylation and transcriptional alterations of pediatric central nervous system tumors.
Lee MK, Azizgolshani N, Zhang Z, Perreard L, Kolling FW, Nguyen LN, Zanazzi GJ, Salas LA, Christensen BCNat Commun. 2024 Apr 30;15(1):3635. doi: 10.1038/s41467-024-47943-9. Epub 2024 Apr 30.
PMID: 38688903
Enrichment of a neutrophil-like monocyte transcriptional state in glioblastoma myeloid suppressor cells.
Wiencke JK, Nissen E, Koestler DC, Tamaki SJ, Tamaki CM, Hansen HM, Warrier G, Hadad S, McCoy L, Rice T, Clarke J, Taylor JW, Salas LA, Christensen BC, Kelsey KT, Butler R, Molinaro AMRes Sq. 2023 Dec 28; pii: rs.3.rs-3793353. doi: 10.21203/rs.3.rs-3793353/v1. Epub 2023 Dec 28.
PMID: 38234734
Matched analysis of detailed peripheral blood and tumor immune microenvironment profiles in bladder cancer.
Chen JQ, Salas LA, Wiencke JK, Koestler DC, Molinaro AM, Andrew AS, Seigne JD, Karagas MR, Kelsey KT, Christensen BCEpigenomics. 2024 Jan;16(1):41-56. doi: 10.2217/epi-2023-0358. Epub 2024 Jan 15.
PMID: 38221889
Immunological shifts during early-stage Parkinson's disease identified with DNA methylation data on longitudinally collected blood samples.
Pike SC, Havrda M, Gilli F, Zhang Z, Salas LANPJ Parkinsons Dis. 2024 Jan 11;10(1):21. doi: 10.1038/s41531-023-00626-6. Epub 2024 Jan 11.
PMID: 38212355
Tumor microenvironment deconvolution identifies cell-type-independent aberrant DNA methylation and gene expression in prostate cancer.
Reynolds SR, Zhang Z, Salas LA, Christensen BCClin Epigenetics. 2024 Jan 3;16(1):5. doi: 10.1186/s13148-023-01609-3. Epub 2024 Jan 3.
PMID: 38173042
Potential to Enhance Large Scale Molecular Assessments of Skin Photoaging through Virtual Inference of Spatial Transcriptomics from Routine Staining.
Srinivasan G, Davis MJ, LeBoeuf MR, Fatemi M, Azher ZL, Lu Y, Diallo AB, Saldias Montivero MK, Kolling FW, Perrard L, Salas LA, Christensen BC, Palys TJ, Karagas MR, Palisoul SM, Tsongalis GJ, Vaickus LJ, Preum SM, Levy JJPac Symp Biocomput. 2024;29:477-491.
PMID: 38160301
Spatial Omics Driven Crossmodal Pretraining Applied to Graph-based Deep Learning for Cancer Pathology Analysis.
Azher ZL, Fatemi M, Lu Y, Srinivasan G, Diallo AB, Christensen BC, Salas LA, Kolling FW, Perreard L, Palisoul SM, Vaickus LJ, Levy JJPac Symp Biocomput. 2024;29:464-476.
PMID: 38160300
Deciphering the role of immune cell composition in epigenetic age acceleration: Insights from cell-type deconvolution applied to human blood epigenetic clocks.
Zhang Z, Reynolds SR, Stolrow HG, Chen JQ, Christensen BC, Salas LAAging Cell. 2024 Mar;23(3):e14071. doi: 10.1111/acel.14071. Epub 2023 Dec 25.
PMID: 38146185
