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Incorporation of Fluorinated Nucleotide Analogs Into HIV-1 TAR RNA

Incorporation of Fluorinated Nucleotide Analogs Into HIV-1 TAR RNA

Abstract Tat is an 86 amino acid virally encoded protein vital to the human immunodeficiency virus type 1 (HIV-1) life cycle by stimulating transcription initiation and increases processivity of ribonucleic acid (RNA) polymerase II. Tat is introduced to the endogenous transcription machinery upon binding of the RNA stem-loop TAR. The […]

Ooid Production and Transport on the Caicos Platform

ABSTRACT Limestone is common in rocks from all geologic periods of the Phanerozoic era as well as in many Proterozoic assemblages (1). The minerologic and fabric character of these limestones generally reflect the complex biological, physical, and climactic character of the depositional systems under which they were created. Of particular […]

Does Irrigation Development Decrease Local Malaria Infection Rates?

Abstract In sub-Saharan Africa, arid soil coupled with a rapidly increasing demand for food has driven the development of small and large-scale irrigation schemes. Irrigation development has the potential to increase or decrease local malaria infection rates and this paper uses two conflicting case studies to identify four factors which […]

The Life and Death of the Cholera Pathogen

Dirty water has a profound effect on the lives of the global majority. Waterborne disease takes lives directly (1), and further weakens or kills those affected by HIV/AIDS, malaria, and malnutrition (2, 3). Viral, bacterial, prion, fungal, and protozoan waterborne diseases can be eliminated simultaneously with the provision of clean […]

Remember When?: Infantile Amnesia

Introduction Memory. It is the internal scrapbook that defines one’s individuality—a sense of self that is crucial to the human psyche. Nevertheless, due in large part to its longevity, memory is a difficult term to define. It appears to be ineffaceable, a solid entity of the past, yet it frequently […]

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