酸素は血中にも溶存していると考えられるが，酸素の運搬を主に担っているのは赤血球である．赤血球はヘム鉄を内包しており，ヘム鉄が酸素と結合することで効率的に酸素を運搬できるようになっている．
ヘム鉄の形成に必要な元素に鉄がある．体内の貯蔵鉄は分解された赤血球から回収され再利用されているが，経血などで体外に失われることが知られており，鉄分を含んだ食品からの摂取が欠かせないと考えられている．
鉄は血液の血清成分に溶解して存在する．フェリチン（フェリチン鉄）と呼ばれるタンパク質は血中の鉄分に結合して効率よく鉄分を運搬する．このため体内の鉄分が減少して鉄欠乏状態となると，古典的にはフェリチン，血清鉄の順番で低下が認められる．また，フェリチンは体内の炎症を鋭敏に反映することがあるため，慢性炎症を抱えているとフェリチン値に上昇を認めるため，フェリチン値高値だけを見て鉄が充足しているとは安易に判断できない．
40歳以上の方限定 無料生活習慣病検診実施中！
Multicellular organisms require multiple cells, tissues, and organs to work in an organically related manner. Therefore, the cells are differentiated so that they have their own unique properties, and they are responsible for their respective functions. Organs, tissues, and cells such as the heart, lungs, lymphatic system including spleen and lymph nodes, blood vessels, and blood cells are responsible for transporting oxygen to peripheral tissues via blood circulation.
Oxygen could be dissolved in blood, but red blood cells are mainly responsible for transporting oxygen. Erythrocytes contain heme iron, and when heme iron binds with oxygen, oxygen can be efficiently transported.
Iron is an element necessary for the formation of heme iron. The stored iron in the body is recovered from the degraded erythrocytes and reused in many times, but as you know, it could be lost to the outside of the body due to mense, and it is considered that intake from foods containing iron is indispensable.
Inorganic Iron exists in the serum. A protein called ferritin (ferritin iron) binds to iron in blood and efficiently transports iron. Therefore, when iron content in the body decreases and iron deficiency occurs, classically, ferritin and serum iron decrease in order. In addition, since ferritin may sensitively reflect inflammation in the body, ferritin levels are elevated when chronic inflammation is present, so it is not easy to judge that iron is sufficient by observing only high ferritin levels.
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