Cheap flights from Knoxville to St. Louis

Flights overview

Useful information for finding cheap flights from Knoxville to St. Louis and booking your next trip
Cheapest round-trip flights $180
Frontier 1 stop 24 hr Mon, Jun 1 — Tue, Jun 9
The cheapest round-trip flight from Knoxville to St. Louis is currently $180
Cheapest one-way flight $96
Frontier 1 stop 24 hr Fri, Jun 5
The cheapest one-way flight from Knoxville to St. Louis is currently $96
Last-minute weekend getaway $340
Frontier 1 stop 24 hr Fri, May 8 — Sun, May 10
The cheapest last-minute weekend getaway from Knoxville to St. Louis is currently $340
Cheapest business class flights $470
American 1 stop 5 hr Mon, Jun 1 — Tue, Jun 9
The cheapest business class round-trip flight from Knoxville to St. Louis is currently $470
Fastest flight 3 hr 10 min The fastest flight with stops from Knoxville to St. Louis takes 3 hr 10 min
Nonstop flights None There are no direct flights on this route.

When is the cheapest time to fly?

The cheapest month to fly from Knoxville to St. Louis is typically January. The most expensive month to fly is typically March.
January
Cheapest
Typical prices: $225–435
March
Most expensive
Typical prices: $255–485

Popular airlines from Knoxville to St. Louis

  • American
    from $299
    Typical price: $230–480
    506 weekly connecting flights
    TYS - STL Every day
  • Delta
    from $311
    Typical price: $250–550
    291 weekly connecting flights
    TYS - STL Every day
  • United
    from $294
    Typical price: $275–590
    243 weekly connecting flights
    TYS - STL Every day
  • Southwest
    from $263
    Typical price: $265–475
    170 weekly connecting flights
    TYS - STL Every day
  • Frontier
    from $230
    Typical price: $205–500
    2 weekly connecting flights
    TYS - STL Every Fri, Sun

Popular airports near Knoxville

  • McGhee Tyson Airport (TYS)
    Knoxville United States 21 min 11 mi
  • Nashville International Airport (BNA)
    Nashville United States 2 hr 38 min 154 mi
  • Hartsfield-Jackson Atlanta International Airport (ATL)
    Atlanta United States 3 hr 23 min 163 mi
  • Chattanooga Metropolitan Airport (CHA)
    Chattanooga United States 1 hr 39 min 96 mi

Popular airports near St. Louis

  • St. Louis Lambert International Airport (STL)
    St. Louis United States 21 min 12 mi
  • General Wayne A. Downing Peoria International Airport (PIA)
    Peoria United States 2 hr 36 min 143 mi
  • Columbia Regional Airport (COU)
    Columbia United States 2 hr 8 min 109 mi
  • Indianapolis International Airport (IND)
    Indianapolis United States 3 hr 30 min 222 mi

Frequently asked questions about flying from Knoxville to St. Louis

The cheapest flights from Knoxville to St. Louis are usually in January. Typical ticket prices in January range from $225 to $435.
The cheapest round-trip flight from Knoxville to St. Louis recently found on Google Flights was with Frontier from $180. The cheapest one-way flight was with Frontier from $96.

Some of the cheapest round-trip deals we found with different airlines:
  • The cheapest American flight from Knoxville to St. Louis is $299, flying from Jul 16 to Jul 22.
  • The cheapest Delta flight from Knoxville to St. Louis is $311, flying from Jul 2 to Jul 8.
  • The cheapest United flight from Knoxville to St. Louis is $294, flying from May 25 to Jun 2.
  • The cheapest Southwest flight from Knoxville to St. Louis is $263, flying from May 28 to Jun 3.
  • The cheapest Frontier flight from Knoxville to St. Louis is $230, flying from Jul 10 to Jul 19.
The cheapest round-trip flight from Knoxville to St. Louis starts at $180 from Mon, Jun 1 to Tue, Jun 9. The cheapest one-way flight starts at $96 and departs on Fri, Jun 5.
3 hr 10 min is the shortest flight time from Knoxville to St. Louis.
Apr–Sep is the most popular time to visit, coinciding with hot, humid summer and events like Fair St. Louis, a huge Fourth of July festival at Forest Park, and the Taste of St. Louis food festival (Sep). Weather in winter is cold, with occasional snow.
It's easy to use Google Flights to find the cheapest days to fly from Knoxville to St. Louis.
Just click the Departure label near the top of the page to open the calendar. Choose a start date and a return date to see how the round-trip fare changes on those specific days.
Adjust the trip type to see one-way fares. The cheapest available flights are highlighted and easy to spot. Once you settle on dates, click the Search button to see flight options and book the deal.

You can also turn on price tracking to get alerts if the price changes for a route or flight.
What counts as the best airline for your flights from Knoxville to St. Louis really depends on your individual needs. You may have a favorite carrier or a loyalty program you like, but price, convenience, and airports served also come into play. Flexibility and booking terms – Can you change flights if you want to stay longer or get a refund if you have to postpone your trip? – are also factors that help determine which airline is best to fly from Knoxville to St. Louis.

In terms of flights, American is the most popular. American offers 506 connecting flights per week. American flies from McGhee Tyson Airport (TYS) to St. Louis Lambert International Airport (STL) .

Other popular airlines flying from Knoxville to St. Louis are:
  • Delta offers 291 connecting flights per week. Delta flies from McGhee Tyson Airport (TYS) to St. Louis Lambert International Airport (STL) .
  • United offers 243 connecting flights per week. United flies from McGhee Tyson Airport (TYS) to St. Louis Lambert International Airport (STL) .
  • Southwest offers 170 connecting flights per week. Southwest flies from McGhee Tyson Airport (TYS) to St. Louis Lambert International Airport (STL) .
  • Frontier offers 2 connecting flights per week. Frontier flies from McGhee Tyson Airport (TYS) to St. Louis Lambert International Airport (STL) .
The number of connecting flights refers to distinct flights with at least one stop between Knoxville and St. Louis.
The cheapest round-trip flight from Knoxville to St. Louis recently found on Google Flights was with Frontier from $180. The cheapest one-way flight was with Frontier from $96.

Some of the cheapest round-trip deals we found with different airlines:
  • The cheapest American flight from Knoxville to St. Louis is $299, flying from Jul 16 to Jul 22.
  • The cheapest Delta flight from Knoxville to St. Louis is $311, flying from Jul 2 to Jul 8.
  • The cheapest United flight from Knoxville to St. Louis is $294, flying from May 25 to Jun 2.
  • The cheapest Southwest flight from Knoxville to St. Louis is $263, flying from May 28 to Jun 3.
  • The cheapest Frontier flight from Knoxville to St. Louis is $230, flying from Jul 10 to Jul 19.
No airline flies direct from Knoxville to St. Louis.
  • There are 506 American connecting flights from Knoxville to St. Louis per week. Flights are available every day.
  • There are 291 Delta connecting flights from Knoxville to St. Louis per week. Flights are available every day.
  • There are 243 United connecting flights from Knoxville to St. Louis per week. Flights are available every day.
  • There are 170 Southwest connecting flights from Knoxville to St. Louis per week. Flights are available every day.
  • There are 2 Frontier connecting flights from Knoxville to St. Louis per week. Flights are available on Friday and Sunday.
Use the Stops filter while searching for flights, to see only nonstop options in your results.
The cheapest last-minute deal between Knoxville and St. Louis at price $340 is offered by Frontier from Fri, May 8 to Sun, May 10.
No airline flies direct from Knoxville to St. Louis.
  • There are 506 American connecting flights from Knoxville to St. Louis per week. Flights are available every day.
  • There are 291 Delta connecting flights from Knoxville to St. Louis per week. Flights are available every day.
  • There are 243 United connecting flights from Knoxville to St. Louis per week. Flights are available every day.
  • There are 170 Southwest connecting flights from Knoxville to St. Louis per week. Flights are available every day.
  • There are 2 Frontier connecting flights from Knoxville to St. Louis per week. Flights are available on Friday and Sunday.
Use the Stops filter while searching for flights, to see only nonstop options in your results.
There are no direct flights from Knoxville to St. Louis.
It's easy to find nonstop flights with Google Flights! Once you've searched for flights from Knoxville to St. Louis, just select the nonstop flights only option in the 'Stops’ filter in the search form and view all available direct flights and their prices.
The cheapest business class round-trip flights between Knoxville and St. Louis start at $470 from Mon, Jun 1 to Tue, Jun 9 with American.
The cheapest economy class round-trip flights between Knoxville and St. Louis start at $180 from Mon, Jun 1 to Tue, Jun 9.
To book business class trips from Knoxville to St. Louis, look for the default Economy selection at the top, and change it to your desired cabin class such as Premium Economy, Business Class, or First Class. You can then select your departure and arrival dates, consider available options, and book your business travel.

You can also adjust the trip type to view one-way fares.
The best last-minute getaway deal for the next weekend between Knoxville and St. Louis starts at $340 from Fri, May 8 to Sun, May 10 with Frontier.
The cheapest last-minute deal between Knoxville and St. Louis at price $340 is offered by Frontier from Fri, May 8 to Sun, May 10.
To find last-minute flight deals from Knoxville to St. Louis, start by entering the city names, select the desired departure and return dates, and hit the Search button to view flight options.

You can check for last-minute flights for the same day or adjust the trip type to see one-way fares.

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