TY - GEN AU - Mazzilli, S. AU - Chiara, P. AU - Costanza, G. AU - Petruzzellis, A. AU - Orlandi, A. AU - Bianchi, L. AU - Campione, E. AU - Gonzalez, S. AU - Pasquali, P. T1 - Overview of germline and somatic genetic alterations in basal and squamous cell carcinoma: a review of the current literature LA - eng PY - 2021/07/01/ SP - 447 EP - 456 T2 - European Journal of Dermatology SN - 1952-4013 VL - 31 IS - 4 PB - John Libbey AB - Non-melanoma skin cancers (NMSCs), including basal and squamous cell carcinomas, represent the most common malignancies among Caucasians. Over two million cases of NMSC occur each year in the US, with a progressive increase in incidence. There are well-known environmental risk factors, such as iatrogenic or ionizing radiation exposure, but the effect of chronic ultraviolet radiation, especially ultraviolet B radiation, is one of the main predisposing factors. Currently, based on our knowledge of the pathophysiology of most NMSCs, we have a better understanding of the associated genetic risk factors. The aim of this study was to evaluate the factors that contribute to the onset of NMSC through a comprehensive literature research. DO - 10.1684/EJD.2021.4092 UR - https://portalcientifico.uah.es/documentos/61a5253f37d5b2018338e9b6 DP - Dialnet - Portal de la Investigación ER -