TY - JOUR AU - Madrid, L. AU - Pinto-Díez, C. AU - Muñoz-Moreno, L. AU - García-Hernández, M. AU - González, V.M. AU - Mata, J.D.L. AU - Martin, M.E. AU - Ortega, P. KW - aptamer KW - carbosilane KW - dendritc system KW - transfection T1 - Cationic Carbosilane Dendrimers for Apmnkq2 Aptamer Transfection in Breast Cancer: An Alternative to Traditional Transfectants. LA - eng PY - 2025/01/01/ T2 - Macromolecular Bioscience SN - 1616-5195 VL - 25 IS - 1 PB - John Wiley and Sons Inc AB - Transfection efficiency is a critical parameter in gene therapy and molecular biology, representing the success rate at which nucleic acids are introduced and expressed in target cells. The combination of aptamers with nanotechnology-based delivery systems has demonstrated remarkable improvements in the transfection efficiency of therapeutic agents and holds significant potential for advancing gene therapy and the development of targeted treatments for various diseases, including cancer. In this work, cationic carbosilane dendritic systems are presented as an alternative to commercial transfection agents, demonstrating an increase in transfection efficiency when used for the internalization of apMNKQ2, an aptamer selected against a target in cancer. Their potential therapeutic use has been evaluated in breast cancer cell lines, MDA-MB-468 and MDA-MB-231, studying the cytotoxicity of the nanoconjugate, the internalization process, and its effect on cellular migration processes. DO - 10.1002/MABI.202400327 UR - https://portalcientifico.uah.es/documentos/6727e9d87903a32777752ecc DP - Dialnet - Portal de la Investigación ER -