TY - GEN AU - Villa-Gonzalez,J.M. AU - Gonzalez-Hermosa,M.R. AU - Ardigò,M. AU - Gonzalez,S. KW - Actinic keratosis KW - Basal cell carcinoma KW - Non-invasive therapy KW - Non-melanocytic skin cancer KW - Reflectance confocal microscopy KW - Squamous cell carcinoma T1 - Monitoring the Effectiveness of Noninvasive or Minimally Invasive Therapies for Nonmelanocytic Lesions Using Reflectance Confocal Microscopy: A Systematic Review LA - eng PY - 2026/01/01/ T2 - Actas Dermo-Sifiliograficas SN - 1578-2190 VL - 117 IS - 1 PB - Elsevier Espana S.L.U AB - In vivo reflectance confocal microscopy (RCM) enables monitoring of non-melanocytic skin cancers (NMSC) treated with non-invasive or minimally invasive therapies. This systematic review analyzed studies on NMSC treated with these therapies and monitored by RCM. A total of 56 articles were included, with 40 focusing on squamous conditions, such as actinic keratosis and squamous cell carcinoma, 15 on basal cell carcinoma (BCC), and 1 on extramammary Paget's disease. Evaluated therapies included ablative laser, cryosurgery, photodynamic therapy, 5-fluorouracil, imiquimod, and tirbanibulin, among others. RCM demonstrated complete response in squamous conditions with normalization of the honeycomb pattern and reduction of scaling and parakeratosis, frequently allowing for detection of subclinical malignancy. In BCC, RCM showed complete response as disappearance of tumor islands. RCM allows treatment optimization and early monitoring, even when inflammation hinders clinical assessment. It is recommended that RCM evaluations be performed starting at least 1 month after treatment for squamous conditions and 3 months for BCC. DO - 10.1016/J.AD.2025.104492 UR - https://portalcientifico.uah.es/documentos/697e9dfb4f95b66d0e7b4261 DP - Dialnet - Portal de la Investigación ER -