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H-E-B Pharmacy Pharmacy ·$$

H-E-B Pharmacy was ranked #1 in customer satisfaction for supermarket pharmacies by J.D. Power for the 3rd year in a row in 2023. At your nearby H-E-B Pharmacy located at 20935 US Highway 281 North in San Antonio, the health and safety of Texans is our top priority. As a trusted source for all routine childhood and adult immunizations, H-E-B Pharmacy is also a provider for COVID 19 vaccine. H-E-B is proud to continue our long-term tradition of taking care of Texans.

Website: heb.com

Phone: (210) 491-2450

Cross Streets: Near the intersection of US Highway 281 N and Market Rdg

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Closed now

  • Fri 8:00 AM - 8:00 PM

20935 US Highway 281 N San Antonio, TX 78258 ·1235.53 mi

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Reviews

yelp
3.0 29 reviews
5 star
8 4 star
6 3 star
1 2 star
2 1 star
12
Curt C. 01/02/13

This place is humongous! They've got everything you could ever need. It's like an appliance store and a HEB got it on, and produced this behemoth. They've got aisle after aisle of electronics,...

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Diana D. 12/21/25

I would not give them any stars if it were possible! i was in line to pick up a prescription before 5. The pharmacy tech apologized and asked me to come back tomorrow to pick up my meds as it had...

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Morghanne T. 08/22/25

Nobody answers the phone!!! Called numerous times at different times for over a week. No answer! Also submitted for RX for insulin and nobody reached out to me or my doctor to inform us it's...

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Patrick M. 08/21/22

Most every H-E-B store I have been to have been great. There are some really stellar H-E-B stores around. I shopped this one for the first time a couple weeks ago. This H‑E‑B Plus! Store is huge...

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Julie C. 04/03/25

Glad the pharmacy wasn't busy the woman at the counter wouldn't have had time to take her break and hang out with her friend while I waited

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