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Two slices (from left to right): one slice of Serrano's, one slice of Americana; $25 after taxes.
Mushrooms/sausages pizza
Dry ass
Cheese slice
Mushrooms/artichoke pizza
Menu
Fresh Choice Pizza
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Serrano's Pizza Pizza ·$

Serrano's Pizza The city of San Francisco has its fair share of Italian eateries, notably in the heritage-driven North Beach district. But Serrano's Pizza has been satisfying the Mission area's cravings for delicious pizzas, pastas, calzones and more since 1999, evolving to become the community's go-to "by-the-slice" parlor. Serrano's is ready to serve up whatever is on your taste buds agenda - a quick slice, a unique or special pasta creation or even a crisp, fresh salad. With a nearly infinite number of topping, cheese and sauce combinations, building a "customized" pizza has become a favorite activity for our regulars. What other pizza place refuses to reheat cold pies for slices? Serrano's pizza chefs make every order for individual slices fresh- from scratch! We're also the home of San Francisco's extra-large pizza at a whopping 18-inches...if that doesn't take care of the party-goers at your celebration, nothing will!.. More About Us! Specialized pizzas are also one of the unique draws of Serrano's that keeps our customers coming back time and again. Perhaps nowhere else in the City by the Bay will you find such an exotic collection of out-of-the-ordinary pies - from Hawaiian, Margarita, Garden, Americana, "Art & Tom Terrific" and Clam Bake variants to Greek, San Franciscan, Prima, Crazy Pollo, Pesto Delight, Chef, Portuguese and many, many more.

Website: serranospizza.biz

Phone: (415) 695-1615

Cross Streets: Near the intersection of 21st St and Lexington St

Interested in our services?

Open now

  • Thu 11:00 AM - 11:00 PM

3274 21st St San Francisco, CA 94110 ·2345.64 mi

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Amenities

  • Accessible
  • Family friendly

Reviews

yelp
3.5 700 reviews
5 star
269 4 star
202 3 star
76 2 star
55 1 star
98
Andrea B. 06/14/26

A good bang for your buck. This is one of my go to places to grab a slice (or two). I consider it to be 2 slices because they're HUGE. We got a slice of pepperoni, olives, and pineapple and...

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Hansel F. 05/23/26

Locals love this pizza shop in the mission. Quick and easy for eating in and to-go. There's a little room to eat inside but most take it out. $7 for a slice of cheese surprised me until I saw the...

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William B. 09/20/25

When U Mention What Is My All Time Favorite Food Of All Time For Me That Would Be P-ì-ź-ź-ą & I Have Visited A Whole Bunch Of Pizza Locations All Over The States & Also Ate Pizza On A Cruise...

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Jazlene T. 07/10/26

Awkward service but I surprisingly really liked their pizza. They have huge slices and it's filling for sure. It's pretty greasy but it seems like a good choice for a long night out.

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Brandi H. 07/26/25

We just happened to be parked infront of Serrano's so we thought why not get a late night snack. I've never heard or seen this spot but there seemed to be a steady flow of customers. We got a...

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