Cheap flights from Mexico City to Santa Cruz de la Sierra

Flights overview

Useful information for finding cheap flights from Mexico City to Santa Cruz de la Sierra and booking your next trip
Cheapest round-trip flights $562
COPA 1 stop 15 hr Thu, May 7 — Thu, May 21
The cheapest round-trip flight from Mexico City to Santa Cruz de la Sierra is currently $562
Cheapest one-way flight $301
COPA 1 stop 20 hr Wed, May 6
The cheapest one-way flight from Mexico City to Santa Cruz de la Sierra is currently $301
Last-minute weekend getaway $562
COPA 1 stop 15 hr Thu, May 7 — Mon, May 11
The cheapest last-minute weekend getaway from Mexico City to Santa Cruz de la Sierra is currently $562
Cheapest business class flights $1,164
COPA 1 stop 15 hr Thu, May 7 — Thu, May 21
The cheapest business class round-trip flight from Mexico City to Santa Cruz de la Sierra is currently $1,164
Fastest flight 10 hr 1 min The fastest flight with stops from Mexico City to Santa Cruz de la Sierra takes 10 hr 1 min
Nonstop flights None There are no direct flights on this route.

When is the cheapest time to fly?

The cheapest month to fly from Mexico City to Santa Cruz de la Sierra is typically October. The most expensive month to fly is typically December.
October
Cheapest
Typical prices: $450–680
December
Most expensive
Typical prices: $660–1,350

Popular airlines from Mexico City to Santa Cruz de la Sierra

  • Avianca
    from $579
    Typical price: $500–990
    97 weekly connecting flights
    MEX - VVI Every day
  • COPA
    from $562
    Typical price: $540–1,050
    58 weekly connecting flights
    MEX - VVI Every day
  • LATAM
    from $566
    Typical price: $620–1,250
    9 weekly connecting flights
    MEX - VVI Every day

Popular airports near Mexico City

  • Mexico City International Airport Benito Juárez (MEX)
    Mexico City Mexico 24 min 4 mi
  • Felipe Ángeles International Airport (NLU)
    Mexico City Mexico 1 hr 22 min 23 mi
  • Lic. Adolfo López Mateos International Airport (TLC)
    Mexico City Mexico 1 hr 7 min 29 mi
  • Queretaro International Airport (QRO)
    Santiago de Querétaro Mexico 2 hr 44 min 106 mi

Popular airports near Santa Cruz de la Sierra

  • Viru Viru International Airport (VVI) (VVI)
    Santa Cruz de la Sierra Bolivia 29 min 11 mi

Frequently asked questions about flying from Mexico City to Santa Cruz de la Sierra

The cheapest flights from Mexico City to Santa Cruz de la Sierra are usually in October. Typical ticket prices in October range from $450 to $680.
The cheapest round-trip flight from Mexico City to Santa Cruz de la Sierra recently found on Google Flights was with COPA from $562. The cheapest one-way flight was with COPA from $301.

Some of the cheapest round-trip deals we found with different airlines:
  • The cheapest Avianca flight from Mexico City to Santa Cruz de la Sierra is $579, flying from May 7 to May 20.
  • The cheapest COPA flight from Mexico City to Santa Cruz de la Sierra is $562, flying from May 7 to May 21.
  • The cheapest LATAM flight from Mexico City to Santa Cruz de la Sierra is $566, flying from Jun 4 to Jun 20.
The cheapest round-trip flight from Mexico City to Santa Cruz de la Sierra starts at $562 from Thu, May 7 to Thu, May 21. The cheapest one-way flight starts at $301 and departs on Wed, May 6.
10 hr 1 min is the shortest flight time from Mexico City to Santa Cruz de la Sierra.
Santa Cruz de la Sierra is an all-year destination, with the most popular months being Dec–Jan. The tropical weather is warm-to-hot year-round, with the heaviest rainfall in Dec–Jan. Key annual events include Carnaval (Feb/Mar, dates vary), the Festival de Música Misiones de Chiquitos (Apr–May), celebrating American Renaissance and baroque music, and the city’s independence day (Sep 24).
It's easy to use Google Flights to find the cheapest days to fly from Mexico City to Santa Cruz de la Sierra.
Just click the Departure label near the top of the page to open the calendar. Choose a start date and a return date to see how the round-trip fare changes on those specific days.
Adjust the trip type to see one-way fares. The cheapest available flights are highlighted and easy to spot. Once you settle on dates, click the Search button to see flight options and book the deal.

You can also turn on price tracking to get alerts if the price changes for a route or flight.
What counts as the best airline for your flights from Mexico City to Santa Cruz de la Sierra really depends on your individual needs. You may have a favorite carrier or a loyalty program you like, but price, convenience, and airports served also come into play. Flexibility and booking terms – Can you change flights if you want to stay longer or get a refund if you have to postpone your trip? – are also factors that help determine which airline is best to fly from Mexico City to Santa Cruz de la Sierra.

In terms of flights, Avianca is the most popular. Avianca offers 97 connecting flights per week. Avianca flies from Mexico City International Airport Benito Juárez (MEX) to Viru Viru International Airport (VVI) (VVI) .

Other popular airlines flying from Mexico City to Santa Cruz de la Sierra are:
  • COPA offers 58 connecting flights per week. COPA flies from Mexico City International Airport Benito Juárez (MEX) to Viru Viru International Airport (VVI) (VVI) .
  • LATAM offers 9 connecting flights per week. LATAM flies from Mexico City International Airport Benito Juárez (MEX) to Viru Viru International Airport (VVI) (VVI) .
The number of connecting flights refers to distinct flights with at least one stop between Mexico City and Santa Cruz de la Sierra.
The cheapest round-trip flight from Mexico City to Santa Cruz de la Sierra recently found on Google Flights was with COPA from $562. The cheapest one-way flight was with COPA from $301.

Some of the cheapest round-trip deals we found with different airlines:
  • The cheapest Avianca flight from Mexico City to Santa Cruz de la Sierra is $579, flying from May 7 to May 20.
  • The cheapest COPA flight from Mexico City to Santa Cruz de la Sierra is $562, flying from May 7 to May 21.
  • The cheapest LATAM flight from Mexico City to Santa Cruz de la Sierra is $566, flying from Jun 4 to Jun 20.
No airline flies direct from Mexico City to Santa Cruz de la Sierra.
  • There are 97 Avianca connecting flights from Mexico City to Santa Cruz de la Sierra per week. Flights are available every day.
  • There are 58 COPA connecting flights from Mexico City to Santa Cruz de la Sierra per week. Flights are available every day.
  • There are 9 LATAM connecting flights from Mexico City to Santa Cruz de la Sierra per week. Flights are available every day.
Use the Stops filter while searching for flights, to see only nonstop options in your results.
The cheapest last-minute deal between Mexico City and Santa Cruz de la Sierra at price $562 is offered by COPA from Thu, May 7 to Mon, May 11.
No airline flies direct from Mexico City to Santa Cruz de la Sierra.
  • There are 97 Avianca connecting flights from Mexico City to Santa Cruz de la Sierra per week. Flights are available every day.
  • There are 58 COPA connecting flights from Mexico City to Santa Cruz de la Sierra per week. Flights are available every day.
  • There are 9 LATAM connecting flights from Mexico City to Santa Cruz de la Sierra per week. Flights are available every day.
Use the Stops filter while searching for flights, to see only nonstop options in your results.
There are no direct flights from Mexico City to Santa Cruz de la Sierra.
It's easy to find nonstop flights with Google Flights! Once you've searched for flights from Mexico City to Santa Cruz de la Sierra, just select the nonstop flights only option in the 'Stops’ filter in the search form and view all available direct flights and their prices.
The cheapest business class round-trip flights between Mexico City and Santa Cruz de la Sierra start at $1,164 from Thu, May 7 to Thu, May 21 with COPA.
The cheapest economy class round-trip flights between Mexico City and Santa Cruz de la Sierra start at $562 from Thu, May 7 to Thu, May 21.
To book business class trips from Mexico City to Santa Cruz de la Sierra, look for the default Economy selection at the top, and change it to your desired cabin class such as Premium Economy, Business Class, or First Class. You can then select your departure and arrival dates, consider available options, and book your business travel.

You can also adjust the trip type to view one-way fares.
The best last-minute getaway deal for the next weekend between Mexico City and Santa Cruz de la Sierra starts at $562 from Thu, May 7 to Mon, May 11 with COPA.
The cheapest last-minute deal between Mexico City and Santa Cruz de la Sierra at price $562 is offered by COPA from Thu, May 7 to Mon, May 11.
To find last-minute flight deals from Mexico City to Santa Cruz de la Sierra, start by entering the city names, select the desired departure and return dates, and hit the Search button to view flight options.

You can check for last-minute flights for the same day or adjust the trip type to see one-way fares.

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