Cheap flights from Panama City to St. Louis

Flights overview

Useful information for finding cheap flights from Panama City to St. Louis and booking your next trip
Cheapest round-trip flights $315
Delta 1 stop 5 hr Thu, Jul 2 — Sun, Jul 5
The cheapest round-trip flight from Panama City to St. Louis is currently $315
Cheapest one-way flight $158
United 1 stop 6 hr Wed, Jun 3
The cheapest one-way flight from Panama City to St. Louis is currently $158
Cheapest nonstop flights $379
Southwest Nonstop 2 hr Thu, Jun 4 — Mon, Jun 8
The cheapest nonstop round-trip flight from Panama City to St. Louis is currently $379
Last-minute weekend getaway $439
Delta 1 stop 5 hr Thu, May 7 — Sun, May 10
The cheapest last-minute weekend getaway from Panama City to St. Louis is currently $439
Cheapest business class flights $605
Delta 1 stop 4 hr Thu, Jul 2 — Sun, Jul 5
The cheapest business class round-trip flight from Panama City to St. Louis is currently $605
Fastest flight 1 hr 50 min The fastest nonstop flight from Panama City to St. Louis takes 1 hr 50 min
Nonstop flights Every day There are direct flights on this route every day.

When is the cheapest time to fly?

The cheapest month to fly from Panama City to St. Louis is typically September. The most expensive month to fly is typically January.
September
Cheapest
Typical prices: $155–415
January
Most expensive
Typical prices: $285–435

Popular airlines from Panama City to St. Louis

  • Southwest
    Nonstop
    from $320
    Typical price: $285–470
    9 weekly nonstop flights
    ECP - STL Every day
    507 weekly connecting flights
    ECP - STL Every day
  • Delta
    from $315
    Typical price: $255–570
    238 weekly connecting flights
    ECP - STL Every day
  • American
    from $315
    Typical price: $260–550
    212 weekly connecting flights
    ECP - STL Every day
  • United
    from $317
    Typical price: $310–640
    104 weekly connecting flights
    ECP - STL Every day

Popular airports near Panama City

  • Northwest Florida Beaches International Airport (ECP)
    Panama City United States 37 min 16 mi
  • Destin-Fort Walton Beach Airport (VPS)
    Destin United States 1 hr 45 min 56 mi
  • Pensacola International Airport (PNS)
    Pensacola United States 2 hr 22 min 93 mi
  • Tallahassee International Airport (TLH)
    Tallahassee United States 1 hr 50 min 80 mi

Popular airports near St. Louis

  • St. Louis Lambert International Airport (STL)
    St. Louis United States 21 min 12 mi
  • General Wayne A. Downing Peoria International Airport (PIA)
    Peoria United States 2 hr 36 min 143 mi
  • Columbia Regional Airport (COU)
    Columbia United States 2 hr 8 min 109 mi
  • Indianapolis International Airport (IND)
    Indianapolis United States 3 hr 30 min 222 mi

Frequently asked questions about flying from Panama City to St. Louis

The cheapest flights from Panama City to St. Louis are usually in September. Typical ticket prices in September range from $155 to $415.
The cheapest round-trip flight from Panama City to St. Louis recently found on Google Flights was with Delta from $315. The cheapest one-way flight was with United from $158.

Some of the cheapest round-trip deals we found with different airlines:
  • The cheapest Southwest flight from Panama City to St. Louis is $320, flying from Jul 2 to Jul 5.
  • The cheapest Delta flight from Panama City to St. Louis is $315, flying from Jul 2 to Jul 5.
  • The cheapest American flight from Panama City to St. Louis is $315, flying from Jul 9 to Jul 12.
  • The cheapest United flight from Panama City to St. Louis is $317, flying from May 21 to May 25.
The cheapest round-trip flight from Panama City to St. Louis starts at $315 from Thu, Jul 2 to Sun, Jul 5. The cheapest one-way flight starts at $158 and departs on Wed, Jun 3.
1 hr 50 min is the shortest flight time from Panama City to St. Louis.
Apr–Sep is the most popular time to visit, coinciding with hot, humid summer and events like Fair St. Louis, a huge Fourth of July festival at Forest Park, and the Taste of St. Louis food festival (Sep). Weather in winter is cold, with occasional snow.
It's easy to use Google Flights to find the cheapest days to fly from Panama City to St. Louis.
Just click the Departure label near the top of the page to open the calendar. Choose a start date and a return date to see how the round-trip fare changes on those specific days.
Adjust the trip type to see one-way fares. The cheapest available flights are highlighted and easy to spot. Once you settle on dates, click the Search button to see flight options and book the deal.

You can also turn on price tracking to get alerts if the price changes for a route or flight.
What counts as the best airline for your flights from Panama City to St. Louis really depends on your individual needs. You may have a favorite carrier or a loyalty program you like, but price, convenience, and airports served also come into play. Flexibility and booking terms – Can you change flights if you want to stay longer or get a refund if you have to postpone your trip? – are also factors that help determine which airline is best to fly from Panama City to St. Louis.

In terms of nonstop flights, Southwest is the most popular. Southwest offers 9 nonstop flights and 507 connecting flights per week. Southwest flies from Northwest Florida Beaches International Airport (ECP) to St. Louis Lambert International Airport (STL) .

Other popular airlines flying from Panama City to St. Louis are:
  • Delta offers 238 connecting flights per week. Delta flies from Northwest Florida Beaches International Airport (ECP) to St. Louis Lambert International Airport (STL) .
  • American offers 212 connecting flights per week. American flies from Northwest Florida Beaches International Airport (ECP) to St. Louis Lambert International Airport (STL) .
  • United offers 104 connecting flights per week. United flies from Northwest Florida Beaches International Airport (ECP) to St. Louis Lambert International Airport (STL) .
The number of connecting flights refers to distinct flights with at least one stop between Panama City and St. Louis.
The cheapest round-trip flight from Panama City to St. Louis recently found on Google Flights was with Delta from $315. The cheapest one-way flight was with United from $158.

Some of the cheapest round-trip deals we found with different airlines:
  • The cheapest Southwest flight from Panama City to St. Louis is $320, flying from Jul 2 to Jul 5.
  • The cheapest Delta flight from Panama City to St. Louis is $315, flying from Jul 2 to Jul 5.
  • The cheapest American flight from Panama City to St. Louis is $315, flying from Jul 9 to Jul 12.
  • The cheapest United flight from Panama City to St. Louis is $317, flying from May 21 to May 25.
Southwest flies direct from Panama City to St. Louis.
  • There are 9 Southwest direct flights from Panama City to St. Louis per week. Flights are available every day.
Use the Stops filter while searching for flights, to see only nonstop options in your results.
The cheapest last-minute deal between Panama City and St. Louis at price $439 is offered by Delta from Thu, May 7 to Sun, May 10.
Southwest flies direct from Panama City to St. Louis.
  • There are 9 Southwest direct flights from Panama City to St. Louis per week. Flights are available every day.
Use the Stops filter while searching for flights, to see only nonstop options in your results.
There are direct flights from Panama City to St. Louis on a daily basis.
The cheapest direct (nonstop) round-trip flights between Panama City and St. Louis start at $379 from Thu, Jun 4 to Mon, Jun 8 with Southwest.
It's easy to find nonstop flights with Google Flights! Once you've searched for flights from Panama City to St. Louis, just select the nonstop flights only option in the 'Stops’ filter in the search form and view all available direct flights and their prices.
The cheapest business class round-trip flights between Panama City and St. Louis start at $605 from Thu, Jul 2 to Sun, Jul 5 with Delta.
The cheapest economy class round-trip flights between Panama City and St. Louis start at $315 from Thu, Jul 2 to Sun, Jul 5.
To book business class trips from Panama City to St. Louis, look for the default Economy selection at the top, and change it to your desired cabin class such as Premium Economy, Business Class, or First Class. You can then select your departure and arrival dates, consider available options, and book your business travel.

You can also adjust the trip type to view one-way fares.
The best last-minute getaway deal for the next weekend between Panama City and St. Louis starts at $439 from Thu, May 7 to Sun, May 10 with Delta.
The cheapest last-minute deal between Panama City and St. Louis at price $439 is offered by Delta from Thu, May 7 to Sun, May 10.
To find last-minute flight deals from Panama City to St. Louis, start by entering the city names, select the desired departure and return dates, and hit the Search button to view flight options.

You can check for last-minute flights for the same day or adjust the trip type to see one-way fares.

Search more flights

Popular trips from Panama City

  1. London
    $976
    Aug 13 — Aug 17
    2 stops 15 hr 54 min Air France, Delta
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    2 stops 10 hr 36 min Air France, Delta
  3. Las Vegas
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