Cheap flights from St. Louis to Panama City

Flights overview

Useful information for finding cheap flights from St. Louis to Panama City and booking your next trip
Cheapest round-trip flights $315
Delta 1 stop 5 hr Thu, Jun 4 — Sun, Jun 7
The cheapest round-trip flight from St. Louis to Panama City is currently $315
Cheapest one-way flight $158
American 1 stop 6 hr Wed, Jun 3
The cheapest one-way flight from St. Louis to Panama City is currently $158
Cheapest nonstop flights $467
Southwest Nonstop 2 hr Thu, Jul 9 — Sun, Jul 12
The cheapest nonstop round-trip flight from St. Louis to Panama City is currently $467
Last-minute weekend getaway $439
Delta 1 stop 5 hr Thu, May 7 — Sun, May 10
The cheapest last-minute weekend getaway from St. Louis to Panama City is currently $439
Cheapest business class flights $605
Delta 1 stop 5 hr Thu, Jun 11 — Sun, Jun 14
The cheapest business class round-trip flight from St. Louis to Panama City is currently $605
Fastest flight 1 hr 45 min The fastest nonstop flight from St. Louis to Panama City takes 1 hr 45 min
Nonstop flights Every day There are direct flights on this route every day.

When is the cheapest time to fly?

The cheapest month to fly from St. Louis to Panama City is typically September. The most expensive month to fly is typically April.
September
Cheapest
Typical prices: $175–440
April
Most expensive
Typical prices: $320–470

Popular airlines from St. Louis to Panama City

  • Southwest
    Nonstop
    from $320
    Typical price: $280–485
    9 weekly nonstop flights
    STL - ECP Every day
    562 weekly connecting flights
    STL - ECP Every day
  • American
    from $315
    Typical price: $255–560
    238 weekly connecting flights
    STL - ECP Every day
  • Delta
    from $315
    Typical price: $250–570
    227 weekly connecting flights
    STL - ECP Every day
  • United
    from $439
    Typical price: $310–650
    100 weekly connecting flights
    STL - ECP Every day

Popular airports near St. Louis

  • St. Louis Lambert International Airport (STL)
    St. Louis United States 21 min 12 mi
  • General Wayne A. Downing Peoria International Airport (PIA)
    Peoria United States 2 hr 36 min 143 mi
  • Columbia Regional Airport (COU)
    Columbia United States 2 hr 8 min 109 mi
  • Indianapolis International Airport (IND)
    Indianapolis United States 3 hr 30 min 222 mi

Popular airports near Panama City

  • Northwest Florida Beaches International Airport (ECP)
    Panama City United States 37 min 16 mi
  • Destin-Fort Walton Beach Airport (VPS)
    Destin United States 1 hr 45 min 56 mi
  • Pensacola International Airport (PNS)
    Pensacola United States 2 hr 22 min 93 mi
  • Tallahassee International Airport (TLH)
    Tallahassee United States 1 hr 50 min 80 mi

Frequently asked questions about flying from St. Louis to Panama City

The cheapest flights from St. Louis to Panama City are usually in September. Typical ticket prices in September range from $175 to $440.
The cheapest round-trip flight from St. Louis to Panama City recently found on Google Flights was with Delta from $315. The cheapest one-way flight was with American from $158.

Some of the cheapest round-trip deals we found with different airlines:
  • The cheapest Southwest flight from St. Louis to Panama City is $320, flying from Jul 24 to Jul 27.
  • The cheapest American flight from St. Louis to Panama City is $315, flying from Jul 10 to Jul 13.
  • The cheapest Delta flight from St. Louis to Panama City is $315, flying from Jun 4 to Jun 7.
  • The cheapest United flight from St. Louis to Panama City is $439, flying from May 8 to May 10.
The cheapest round-trip flight from St. Louis to Panama City starts at $315 from Thu, Jun 4 to Sun, Jun 7. The cheapest one-way flight starts at $158 and departs on Wed, Jun 3.
1 hr 45 min is the shortest flight time from St. Louis to Panama City.
Panama City has a sunny subtropical climate and is mild to warm year-round. The most popular time to visit is the summer months of Jun–Jul, and it’s also busy during college spring break (Mar/Apr). Free weekly outdoor concerts are staged at Aaron Bessant Park in Panama City Beach Jun–Aug. The Boat Parade of Lights (Dec) is a floating light show with decorated boats from across Bay County.
It's easy to use Google Flights to find the cheapest days to fly from St. Louis to Panama City.
Just click the Departure label near the top of the page to open the calendar. Choose a start date and a return date to see how the round-trip fare changes on those specific days.
Adjust the trip type to see one-way fares. The cheapest available flights are highlighted and easy to spot. Once you settle on dates, click the Search button to see flight options and book the deal.

You can also turn on price tracking to get alerts if the price changes for a route or flight.
What counts as the best airline for your flights from St. Louis to Panama City really depends on your individual needs. You may have a favorite carrier or a loyalty program you like, but price, convenience, and airports served also come into play. Flexibility and booking terms – Can you change flights if you want to stay longer or get a refund if you have to postpone your trip? – are also factors that help determine which airline is best to fly from St. Louis to Panama City.

In terms of nonstop flights, Southwest is the most popular. Southwest offers 9 nonstop flights and 562 connecting flights per week. Southwest flies from St. Louis Lambert International Airport (STL) to Northwest Florida Beaches International Airport (ECP) .

Other popular airlines flying from St. Louis to Panama City are:
  • American offers 238 connecting flights per week. American flies from St. Louis Lambert International Airport (STL) to Northwest Florida Beaches International Airport (ECP) .
  • Delta offers 227 connecting flights per week. Delta flies from St. Louis Lambert International Airport (STL) to Northwest Florida Beaches International Airport (ECP) .
  • United offers 100 connecting flights per week. United flies from St. Louis Lambert International Airport (STL) to Northwest Florida Beaches International Airport (ECP) .
The number of connecting flights refers to distinct flights with at least one stop between St. Louis and Panama City.
The cheapest round-trip flight from St. Louis to Panama City recently found on Google Flights was with Delta from $315. The cheapest one-way flight was with American from $158.

Some of the cheapest round-trip deals we found with different airlines:
  • The cheapest Southwest flight from St. Louis to Panama City is $320, flying from Jul 24 to Jul 27.
  • The cheapest American flight from St. Louis to Panama City is $315, flying from Jul 10 to Jul 13.
  • The cheapest Delta flight from St. Louis to Panama City is $315, flying from Jun 4 to Jun 7.
  • The cheapest United flight from St. Louis to Panama City is $439, flying from May 8 to May 10.
Southwest flies direct from St. Louis to Panama City.
  • There are 9 Southwest direct flights from St. Louis to Panama City per week. Flights are available every day.
Use the Stops filter while searching for flights, to see only nonstop options in your results.
The cheapest last-minute deal between St. Louis and Panama City at price $439 is offered by Delta from Thu, May 7 to Sun, May 10.
Southwest flies direct from St. Louis to Panama City.
  • There are 9 Southwest direct flights from St. Louis to Panama City per week. Flights are available every day.
Use the Stops filter while searching for flights, to see only nonstop options in your results.
There are direct flights from St. Louis to Panama City on a daily basis.
The cheapest direct (nonstop) round-trip flights between St. Louis and Panama City start at $467 from Thu, Jul 9 to Sun, Jul 12 with Southwest.
It's easy to find nonstop flights with Google Flights! Once you've searched for flights from St. Louis to Panama City, just select the nonstop flights only option in the 'Stops’ filter in the search form and view all available direct flights and their prices.
The cheapest business class round-trip flights between St. Louis and Panama City start at $605 from Thu, Jun 11 to Sun, Jun 14 with Delta.
The cheapest economy class round-trip flights between St. Louis and Panama City start at $315 from Thu, Jun 4 to Sun, Jun 7.
To book business class trips from St. Louis to Panama City, look for the default Economy selection at the top, and change it to your desired cabin class such as Premium Economy, Business Class, or First Class. You can then select your departure and arrival dates, consider available options, and book your business travel.

You can also adjust the trip type to view one-way fares.
The best last-minute getaway deal for the next weekend between St. Louis and Panama City starts at $439 from Thu, May 7 to Sun, May 10 with Delta.
The cheapest last-minute deal between St. Louis and Panama City at price $439 is offered by Delta from Thu, May 7 to Sun, May 10.
To find last-minute flight deals from St. Louis to Panama City, start by entering the city names, select the desired departure and return dates, and hit the Search button to view flight options.

You can check for last-minute flights for the same day or adjust the trip type to see one-way fares.

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