Atopic dermatitis patients is guessed as over 1.60 million in Japan. They are suffered by chronic itch. By the unbearable itch, they scratch often and deeply , and their skin become miserable. The researchers of Kyushu University found the origin of itching using mouse models of atopic dermatitis. It was reported on Nature July ,2015. They found that reactive astrogliosis depended on the activation of the STAT3, and the reactive state of astrocytes in the dorsal horn of the spinal segments corresponded to lesioned, itchy skin. It means we can ameliorate the chronic severe itch to inhibit the spinal STAT3.