BLACKSBURG, VA — No. 17 Louisville football's running backs room hasn't been healthy for most of the season, and could take another hit.
Cardinals head coach Jeff Brohm said Isaac Brown "might be out for a little while" after the team's 28-16 win over Virginia Tech on Saturday evening.
Brown scored the team's first touchdown on a 52-yard run and finished with 126 rushing yards for his fifth 100-yard rushing performance of the season. He's also totaled 100 or more rushing yards in 10 of his 21 collegiate games. But after a 6-yard run with 5:50 left in the fourth quarter, the sophomore was tackled on VT's sideline and stayed down for a couple minutes. He was able to get up on his own but walked gingerly, favoring his right leg.
"Unfortunately, hurt his leg there," Brohm said. "I anticipate him being out for a while."
Brown had previously battled a lower leg injury, which limited Louisville 's run game to a combined 107 rushing yards against Pitt and Virginia. Louisville is already down one running back. Duke Watson hasn't played in three weeks and left the games against the Panthers and Cavaliers early with a right ankle injury.
If Isaac Brown is unable to go next week against California , Keyjuan Brown is expected to get his second career start and first since the Cardinals' Week 4 game against Bowling Green. He had 84 yards and two touchdowns on 12 carries in the contest. He also had the game-sealing, 24-yard touchdown against Virginia Tech on Saturday, totaling 94 yards and two scores on 12 carries.
"He's a powerful back and I think he has pretty good vision in the backfield," Brohm said of Keyjuan Brown . "He's made some big runs for us the last two games. We're going to have to ride him even more as we get going and progress."
Louisville returns home to host the Golden Bears at 7 p.m. next Saturday.
Reach Louisville football , women's basketball and baseball beat writer Alexis Cubit at acubit@gannett.com and follow her on X at @Alexis_Cubit.
This article originally appeared on Louisville Courier Journal: Jeff Brohm on Isaac Brown injury in Louisville win at Virginia Tech

