The Kansas City Chiefs (5-3) have a crucial road game against the Buffalo Bills (5-2) on Sunday. Isiah Pacheco's injury status at the running back position has been a big storyline all week heading into the AFC showdown, which kicks off at 4:25 p.m. ET on CBS.
Quarterback Patrick Mahomes and backfield partner Kareem Hunt lead the Chiefs with four rushing touchdowns each, but Pacheco is Kansas City's highest-volume rusher this season with 78 carries for 329 yards and one touchdown of his own.
Pacheco's presence grew during the Chiefs' three-game winning streak. He posted more yards each game on the way to a season-high 58 yards on 12 carries against the Washington Commanders last week.
Kansas City Chiefs running back Isiah Pacheco (10). Jay Biggerstaff-Imagn Images
Pacheco sustained an MCL sprain during the win against the Commanders on Monday night and was officially ruled out for the Bills game with the knee injury. On Sunday morning, NFL on CBS sideline reporter Tracy Wolfson revealed an update from head coach Andy Reid just hours before kickoff that was good news for Pacheco.
"Isaiah [sic] Pacheco OUT for today's game but Andy Reid telling me he avoided serious injury and should be back after the bye," Wolfson posted on X. "Expect Kareem Hunt , Brashard Smith and Clyde Edwards-Helaire to carry the load."
The news that Pacheco avoided serious injury will be a huge sigh of relief because he has been there before. Last year, he missed nine games with a fractured fibula. He returned in Week 13 but did not score a touchdown across the rest of the season and the Chiefs' postseason march to Super Bowl LIX.
Regardless whether Kansas City can escape from Buffalo with a win on Sunday, the Chiefs will enter their Week 10 bye with the knowledge that Pacheco is on his way back. Their offense should be closer to full strength when they return to action for an AFC West divisional showdown in Week 11 against the Denver Broncos .
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This story was originally reported by Athlon Sports on Nov 2, 2025, where it first appeared in the NFL section. Add Athlon Sports as a Preferred Source by clicking here.

