College Football Bets: ATS Picks for Top-25 Week 10 Games

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College Football Bets: ATS Picks for Top-25 Week 10 Games

Kyle Wood · Athlon Sports

Wed, Oct 29, 2025 ·

4 min read

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Some of the Week 10 games penciled in the preseason as marquee matchups have lost quite a bit of their luster as the season has unfolded.

Penn State at Ohio State was a matchup between the preseason No. 2 and 3 teams in the country. While the Buckeyes have ascended to the No. 1 spot, the Nittany Lions have dropped out of the rankings entirely ( and fired their head coach ).

The same can be said for the Florida-Georgia game — or the Georgia-Florida game, depending on your perspective. Though still a heated rivalry, that preseason top-15 matchup is now between the No. 5 Bulldogs and an unranked Gators team... that also fired its head coach .

Even South Carolina against Ole Miss was supposed to have huge ramifications in the SEC race. But the Gamecocks have plummeted out of the top 25, while the Rebels have ascended to No. 7.

But fear not, because other games on the schedule have taken on newfound importance that were not foreseen before the season began. No. 9 Vanderbilt can knock No. 20 Texas out of College Football Playoff contention this weekend. The Commodores are rolling while the Longhorns, the preseason No. 1 team in the country, have escaped in overtime in back-to-back games.

Over in the Big 12, No. 17 Cincinnati has emerged as a potential CFP team ahead of a huge road trip to No. 24 Utah. Even No. 15 Virginia's cross-country trip to Cal has taken on new meaning as the Cavaliers have rolled through their ACC schedule, though they've won their last four games by one possession.

BOWL PROJECTIONS: Vanderbilt, Texas A&M Rising in CFP Field

Athlon Sports' writers made their against-the-spread picks for every contest involving a ranked team. They also each landed on a best bet and shared their explanation for their lean below.

Cincinnati quarterback Brendan Sorsby (2) runs with the ball for a touchdown against Baylor at Nippert Stadium on Oct. 25, 2025, in Cincinnati, Ohio.

College Football Predictions: ATS Bets for Week 10 Top-25 Games

		Steven Lassan	Thomas Neumann	Kyle Wood
No. 25 Memphis -13.5	@ Rice	Rice	Memphis	Memphis
No. 5 Georgia -7.5	vs. Florida*	UF	UF	UGA
Penn State	@ No. 21 Ohio State -20.5	Ohio State	Ohio State	Ohio State
No. 9 Vanderbilt	@ No. 20 Texas -1.5	Texas	Vanderbilt	Vanderbilt
No. 10 Miami -10.5	@ SMU	Miami	SMU	Miami
West Virginia	@ No. 22 Houston -14.5	WVU	WVU	Houston
No. 16 Louisville -10.5	@ Virginia Tech	VT	Louisville	VT
No. 2 Indiana -21.5	@ Maryland	Indiana	Indiana	Indiana
No. 12 Notre Dame -28.5	@ Boston College	ND	ND	ND
No. 13 Texas Tech -7.5	@ Kansas State	TTU	TTU	TTU
No. 15 Virginia -4.5	@ California	Cal	Cal	UVA
South Carolina	@ No. 7 Ole Miss -12.5	Ole Miss	SC	SC
Purdue	@ No. 21 Michigan -20.5	Michigan	Purdue	Michigan
No. 8 Georgia Tech -6.5	@ NC State	NC State	NC State	GT
No. 18 Oklahoma	@ No. 14 Tennessee -3.5	OU	OU	Tennessee
No. 23 USC -6.5	@ Nebraska	Nebraska	Nebraska	USC
No. 17 Cincinnati	@ No. 24 Utah -7.5	Cincinnati	Utah	Cincinnati
	Record:	75-81-1	67-89-1	71-85-1

*Neutral site: Jacksonville, Fla.

Week 10 College Football Best Bets

Steven Lassan:No. 23 USC vs. Nebraska - Nebraska +6.5
USC's offense against Nebraska's standout secondary should be a must-see matchup on Saturday night. The Cornhuskers need quarterback Dylan Raiola to play better after an inconsistent stretch, but with this game in Lincoln, along with a secondary that can limit damage through the air, I think coach Matt Rhule's team can at least cover the 6.5 spread.

Thomas Neumann:No. 15 Virginia vs. Cal — Cal +4.5
Virginia has been flirting with disaster of late, with three overtime wins and a two-point victory in its past four games. Now comes a brutal cross-country slog to Berkeley. Look for frosh phenom Jaron-Keawe Sagapolutele and the Bears to bounce back after last week's double-OT loss at Virginia Tech. Engage the #Calgorithm

Kyle Wood:No. 5 Georgia vs. Florida — Georgia -7.5
The Bulldogs, who have dominated the Gators for the past decade and again established themselves as one of the best teams in the country, are barely a touchdown-favorite this Saturday in Jacksonville. Georgia has won the last four meetings by at least 14 points, and Florida carries a losing record heading into this game for the first time since 2017. Maybe the Gators comes out of the gates fired up with interim coach Billy Gonzales in charge, but it's hard to see this one being close.

This story was originally reported by Athlon Sports on Oct 29, 2025, where it first appeared in the College Football section. Add Athlon Sports as a Preferred Source by clicking here.

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