Key Points:
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The Buffalo Bills defeated the Kansas City Chiefs 28-21, ending the Chiefs' three-game win streak.
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Patrick Mahomes struggled with efficiency throughout the game, resulting in a career-low mark.
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The Chiefs fall to 5-4 and will play next against the Denver Broncos after their bye week.
The Buffalo Bills just handed Patrick Mahomes and the Kansas City Chiefs their first loss in four games. The Chiefs entered Sunday's high-profile matchup on a high after winning three in a row, but they finally found their match in Josh Allen and Co.
Despite a respectable effort from the Chiefs, the Bills were able to defend their home field and secure a 28-21 victory. Mahomes finished the loss with 15-of-34 completed passes for 250 yards, zero touchdowns and one interception. It was a forgettable performance for the two-time All-Pro quarterback, who ended up making some unwanted history in the game.
Kansas City Chiefs quarterback Patrick Mahomes yells before a game against the Jacksonville Jaguars.Morgan Tencza-Imagn Images
It was a back-and-forth affair between the Chiefs and the Bills on Sunday. Buffalo opened the scoring at the eight-minute mark of the first quarter. Kansas City, however, took the lead early in the second quarter, 10-7, before conceding two TDs in five minutes.
The Bills scored again in the third quarter, taking a 28-13 lead into the fourth. The Chiefs got one back with more than 11 minutes left in the final frame to make it a one-score game. Buffalo held them off, though, to secure a 28-21 win at Highmark Stadium.
As for Mahomes, the three-time Super Bowl-winning quarterback struggled with his efficiency all game long. He was picked off just once, but he ended up with 19 incomplete passes. This marked a new career low for Mahomes.
According to Chiefs reporter Sam McDowell of The Kansas City Star , this was the first time in Mahomes' nine-year NFL career that he completed less than half of his passes. The former Texas Tech Red Raiders star went 15-of-34 on Sunday for a 44.1% completion rate.
For context, Mahomes entered the Bills game with 189-of-282 completed passes (67.0%). He has a 66.6% career completion rate.
The Chiefs fall to 5-4 after Sunday's loss. They will be on bye in Week 10 and will return to action on Nov. 16 against the red-hot Denver Broncos, who improved to 7-2 after their sixth straight win on Sunday.
Related: Slo-Mo Video of Travis Kelce Hit in Chiefs-Bills Is Hard to Watch
This story was originally reported by Athlon Sports on Nov 3, 2025, where it first appeared in the NFL section. Add Athlon Sports as a Preferred Source by clicking here.
