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Week 6 NFL Best Bets Against the Spread
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- Week 6 NFL Best Bets Against the Spread
Heading into Week 6 of the 2025 NFL season, we continue to track the winning ways of road favorites. After going 3-2 against the spread last week, road favorites are now 16-10 on the season — a winning percentage of .615. By contrast, road favorites for all of the 2024 season were 58-45-4 against the spread, a winning percentage of .563.
The Week 6 schedule features six road favorites. The first one has already gone down, as the Philadelphia Eagles were 7.5-point favorites Thursday night before losing badly to the New York Giants .
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Here are the remaining five road favorites in Week 6:
The one that really jumps out here is the Rams-Ravens line. In the three-year stretch from 2022-24, Baltimore was a home underdog a total of two times. Well, guess what? The Ravens have now been home dogs twice in the last two weeks.
With Lamar Jackson nursing his hamstring injury, Baltimore lost and failed to cover last week against the Houston Texans . With Jackson still out, it gets even worse Sunday as the Ravens host the Los Angeles Rams. Matthew Stafford and the Rams are already 1-0 as a road fave this season — and since 2022, the Rams are 8-1 as a road favorite.
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SEE ALSO: Against the spread picks for every Week 6 game
Check out the best bets this week from Athlon Sports' NFL staff:
Week 6 Best Bets
Luke Easterling 's best NFL picks for Week 6
(Season: 9-6)
Broncos
-7 over Jets
Chargers -4.5 over Dolphins
Patriots -3.5 over Saints
Craig Ellenport 's best NFL picks for Week 6
(Season: 8-7)
Rams -7.5 over Ravens
Buccaneers -3 over 49ers
Bills -4.5 over Falcons
Doug Farrar 's best NFL picks for Week 6
(Season: 5-10)
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Broncos -7 over Jets
Patriots -3.5 over Saints
Colts
-6.5 over Cardinals
Andrew Perloff 's best NFL picks for Week 6
(Season: 5-10)
Steelers
-5.5 over Browns
Seahawks
+1.5 over Jaguars
Bills -4.5 over Falcons
Kyle Wood 's best NFL picks for Week 6
(Season: 6-9)
Seahawks +1.5 over Jaguars
Cowboys -3 over Panthers
Bills -4.5 over Falcons
Week 6 Sunday/Monday slate
Broncos -7 vs. Jets (London)
Browns +5.5 at Steelers
Chargers -4.5 at Dolphins
Patriots -3.5 at Saints
Seahawks +1.5 at Jaguars
Cardinals +6.5 at Colts
Rams -7.5 at Ravens
Cowboys -3 at Panthers
Titans +5.5 at Raiders
49ers +3 at Buccaneers
Bengals
+14.5 at Packers
Lions +2.5 at Chiefs
Bills -4.5 at Falcons
Bears
+4.5 at Commanders
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Related: Week 6 NFL Picks: Expert Picks Against the Spread for Every Game
Related: Red Zone Plus/Minus Rankings NFL Week 5: Colts Take Over Top Spot
This story was originally reported by Athlon Sports on Oct 11, 2025, where it first appeared in the Betting section. Add Athlon Sports as a Preferred Source by clicking here.
