Inter Milan will host Shakhtar Donetsk at San Siro on Wednesday, October 21, in a bid to bounce back from their two defeats in the league phase of the UEFA Champions League.
Last time out in Europe, Cristian Chivu's side was blown out of the water by Club Brugge, though Inter managed to score twice through Lautaro Martínez. The Nerazzurri then rallied to a 3-1 Serie A win over Bologna, but another European defeat would put the pressure on the Italian side.
Shakhtar come to Milan in a stronger mood, having drawn with PSV Eindhoven and beaten AEK Athens 3-1. Arda Turan's side have also won their last home game, which makes it a tough one for Inter.
Inter Milan vs. Shakhtar Donetsk Confirmed Team News and Lineups
Inter Milan predicted XI (3-5-2): Josep Martinez; Yann Bisseck, Manuel Akanji, Alessandro Bastoni; Federico Dimarco, Piotr Zielinski, Nicolo Barella, Petar Sucic, Luis Henrique; Marcus Thuram, Pio Esposito.
Shakhtar Donetsk predicted XI (4-3-3): Dmytro Riznyk; Vinícius Tobias, Valeriy Bondar, Oleksandr Karavaev, Pedro Henrique; Marlon Gomes, Alisson, Dmytro Kryskiv; Kaua Elias, Luca Meirelles, Lassina Traore.

Lautaro Martinez of FC Internazionale looks on during the UEFA Champions League 2026/2027 match between Fc Internazionale and Club Brugge at Stadio San Siro.(Photo by Sportinfoto/DeFodi Images/DeFodi via Getty Images)
Inter will be without captain Lautaro Martínez, who is recovering from a thigh injury. Other reported absentees include John Stones, Benjamin Pavard and Curtis Jones. Shakhtar will be without Eguinaldo and Alaa Ghram, with Marlon Santos and Diego Arroyo both in doubt.
Inter Milan vs. Shakhtar Start Time
The match will kick off at 9 p.m. CEST on Wednesday, October 21, at San Siro in Milan.
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United States (ET): 3 p.m., October 21
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United States (PT): 12 p.m., October 21
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United Kingdom (BST): 8 p.m., October 21
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Brazil (BRT): 4 p.m., October 21
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South Africa (SAST): 9 p.m., October 21
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Saudi Arabia (AST): 10 p.m., October 21
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UAE (GST): 11 p.m., October 21
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India (IST): 12:30 a.m., October 22
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China (CST): 3 a.m., October 22
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Japan (JST): 4 a.m., October 22
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Australia (AEDT): 6 a.m., October 22
How and Where to Watch Inter Milan vs. Shakhtar
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Italy: Amazon Prime Video and Sky Sport.
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United Kingdom: TNT Sports and Amazon Prime Video; BBC has highlights rights.
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United States: Paramount+, TUDN and DAZN.
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India: Sony Sports Network and SonyLIV.
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Canada: DAZN and OneSoccer.
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Australia: Stan Sport.
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Germany: DAZN and Amazon Prime Video.
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Spain: Movistar Plus+.
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Brazil: TNT Sports and SBT.
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South Africa: SuperSport.
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Middle East and North Africa: beIN Sports and beIN CONNECT.
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Japan: WOWOW.
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New Zealand: DAZN.
More Soccer News
This story was originally published by Athlon on Oct 21, 2026, where it first appeared in the Soccer section. Add Athlon as a Preferred Source by clicking here.

