Isaiah Adams Injury Update Could Leave Cardinals Down Two Starters in Week 5

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Isaiah Adams Injury Update Could Leave Cardinals Down Two Starters in Week 5

Neal Coolong · Athlon Sports

Mon, Oct 5, 2026 ·

2 min read

Isaiah Adams injury update

NFL Arizona Cardinals offensive line Isaiah Adams. Mandatory Credit: Mark J. Rebilas-Imagn Images

Adams left in the second quarter Sunday and was carted off the field . He played 28 snaps before the injury and was having a rough day, with a 17.1 pass-blocking grade on 14 pass-blocking snaps, according to PFF.

It's the second injury of the season for the third-year guard. Adams missed the opener with a knee injury and was limited in practice all week before returning in Week 2.

He took over the job in August, when rookie second-round pick Chase Bisontis tore his MCL and was lost for the season.

Who replaces Isaiah Adams at right guard?

Jon Gaines II stepped in against the Giants and played the final 38 snaps. He earned a 46.7 pass-blocking grade, according to PFF, so it wasn't a clean afternoon for him, either.

The Cardinals do trust him. Center Hjalte Froholdt said in August that Gaines "can play all three interior positions" and that "there's not a drop when he goes in there."

The bigger problem is everything happening around him. Left tackle Paris Johnson Jr. is out for the season with a torn biceps, and rookie Jayden Williams is in line to replace him, so Arizona could have new starters at two spots up front.

This story was originally published by Athlon Sports on Oct 5, 2026, where it first appeared in the NFL section. Add Athlon Sports as a Preferred Source by clicking here.