Mahomes' injury occurred in the final two minutes of regulation, when he was rolled up from behind by Chargers defensive linemanDa'Shawn Hand. The veteran quarterback immediately reached for his left knee after falling to the ground and required medical attention before being helped into the locker room.
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Mahomes took to social media to lament the injury, shortly before the Chiefs announced an MRI confirmed the quarterback had suffered a season-ending ACL tear.
"Don't know why this had to happen. And not going to lie [it] hurts," Mahomes wrote. "But all we can do now is Trust in God and attack every single day over and over again."
Kansas City Chiefs quarterback Patrick Mahomes (15) is attended to by team medical staff following an injury during the fourth quarter against the Los Angeles Chargers at GEHA Field at Arrowhead Stadium in Kansas City, Mo. on Dec 14, 2025.
(Jay Biggerstaff, Imagn Images)
Kansas City Chiefs and Chargers players take a knee following an injury to quarterback Patrick Mahomes during the fourth quarter against the Los Angeles Chargers at GEHA Field at Arrowhead Stadium in Kansas City, Mo. on Dec 14, 2025.
(Denny Medley, Imagn Images)
Kansas City Chiefs quarterback Patrick Mahomes (15) is attended to by team medical staff following an injury during the fourth quarter against the Los Angeles Chargers at GEHA Field at Arrowhead Stadium as Kansas City Chiefs head coach Andy Reid, second from right, watches.
(Jay Biggerstaff, Imagn Images)
Kansas City Chiefs quarterback Patrick Mahomes (15) is attended to by team medical staff following an injury during the fourth quarter against the Los Angeles Chargers at GEHA Field at Arrowhead Stadium as Kansas City Chiefs head coach Andy Reid, second from right, stands on the sideline.
(Jay Biggerstaff, Imagn Images)
Los Angeles Chargers linebacker Troy Dye (43) sacks Kansas City Chiefs quarterback Patrick Mahomes (15) during the first quarter at GEHA Field at Arrowhead Stadium in Kansas City, Mo. on Dec 14, 2025..
(Denny Medley, Imagn Images)
Los Angeles Chargers running back Omarion Hampton (8) rushes against Kansas City Chiefs linebacker Drue Tranquill (23) during the second half at GEHA Field at Arrowhead Stadium.
(Jay Biggerstaff, Imagn Images)
Los Angeles Chargers linebacker Odafe Oweh (98) sacks Kansas City Chiefs quarterback Patrick Mahomes (15) during the second half at GEHA Field at Arrowhead Stadium.
(Jay Biggerstaff, Imagn Images)
Kansas City Chiefs head coach Andy Reid reacts to a play against the Los Angeles Chargers during the third quarter at GEHA Field at Arrowhead Stadium in Kansas City, Mo. on Dec 14, 2025..
(Denny Medley, Imagn Images)
Los Angeles Chargers head coach Jim Harbaugh breaks up a confrontation between safety Tony Jefferson (23) and the Kansas City Chiefs during the fourth quarter at GEHA Field at Arrowhead Stadium. Jefferson was subsequently ejected.
(Jay Biggerstaff, Imagn Images)
Los Angeles Chargers running back Omarion Hampton (8) intercepts a pass intended for Kansas City Chiefs running back Kareem Hunt (29) during the fourth quarter at GEHA Field at Arrowhead Stadium.
(Denny Medley, Imagn Images)
Los Angeles Chargers cornerback Cam Hart (20) breaks up a pass intended for Kansas City Chiefs wide receiver Tyquan Thornton (80) during the second quarter at GEHA Field at Arrowhead Stadium.
(Denny Medley, Imagn Images)
Los Angeles Chargers quarterback Justin Herbert (10) passes against the Kansas City Chiefs during the fourth quarter at GEHA Field at Arrowhead Stadium.
(Jay Biggerstaff, Imagn Images)
Kansas City Chiefs tight end Travis Kelce (87) falls to the ground after being tackled against the Los Angeles Chargers during the second half at GEHA Field at Arrowhead Stadium.
(Jay Biggerstaff, Imagn Images)
Los Angeles Chargers safety Derwin James Jr. (3) celebrates with cornerback Donte Jackson (26) and linebacker Daiyan Henley (0) following an interception against the Kansas City Chiefs during the fourth quarter at GEHA Field at Arrowhead Stadium.
(Jay Biggerstaff, Imagn Images)
Kansas City Chiefs head coach Andy Reid, left, and Los Angeles Chargers head coach Jim Harbaugh shake hands following a Chargers victory at GEHA Field at Arrowhead Stadium.
(Jay Biggerstaff, Imagn Images)
Kansas City Chiefs tight end Travis Kelce (87) talks with Los Angeles Chargers safety Derwin James Jr. (3) following a Chargers victory at GEHA Field at Arrowhead Stadium.
(Jay Biggerstaff, Imagn Images)
1/16
Kansas City Chiefs' playoff chances end with Patrick Mahomes injury
Kansas City Chiefs quarterback Patrick Mahomes (15) is attended to by team medical staff following an injury during the fourth quarter against the Los Angeles Chargers at GEHA Field at Arrowhead Stadium in Kansas City, Mo. on Dec 14, 2025.
(Jay Biggerstaff, Imagn Images)
1/16
Kansas City Chiefs' playoff chances end with Patrick Mahomes injury
Kansas City Chiefs quarterback Patrick Mahomes (15) is attended to by team medical staff following an injury during the fourth quarter against the Los Angeles Chargers at GEHA Field at Arrowhead Stadium in Kansas City, Mo. on Dec 14, 2025.
(Jay Biggerstaff, Imagn Images)
2/16
Kansas City Chiefs' playoff chances end with Patrick Mahomes injury
Kansas City Chiefs and Chargers players take a knee following an injury to quarterback Patrick Mahomes during the fourth quarter against the Los Angeles Chargers at GEHA Field at Arrowhead Stadium in Kansas City, Mo. on Dec 14, 2025.
(Denny Medley, Imagn Images)
3/16
Kansas City Chiefs' playoff chances end with Patrick Mahomes injury
Kansas City Chiefs quarterback Patrick Mahomes (15) is attended to by team medical staff following an injury during the fourth quarter against the Los Angeles Chargers at GEHA Field at Arrowhead Stadium as Kansas City Chiefs head coach Andy Reid, second from right, watches.
(Jay Biggerstaff, Imagn Images)
4/16
Kansas City Chiefs' playoff chances end with Patrick Mahomes injury
Kansas City Chiefs quarterback Patrick Mahomes (15) is attended to by team medical staff following an injury during the fourth quarter against the Los Angeles Chargers at GEHA Field at Arrowhead Stadium as Kansas City Chiefs head coach Andy Reid, second from right, stands on the sideline.
(Jay Biggerstaff, Imagn Images)
5/16
Kansas City Chiefs' playoff chances end with Patrick Mahomes injury
Los Angeles Chargers linebacker Troy Dye (43) sacks Kansas City Chiefs quarterback Patrick Mahomes (15) during the first quarter at GEHA Field at Arrowhead Stadium in Kansas City, Mo. on Dec 14, 2025..
(Denny Medley, Imagn Images)
6/16
Kansas City Chiefs' playoff chances end with Patrick Mahomes injury
Los Angeles Chargers running back Omarion Hampton (8) rushes against Kansas City Chiefs linebacker Drue Tranquill (23) during the second half at GEHA Field at Arrowhead Stadium.
(Jay Biggerstaff, Imagn Images)
7/16
Kansas City Chiefs' playoff chances end with Patrick Mahomes injury
Los Angeles Chargers linebacker Odafe Oweh (98) sacks Kansas City Chiefs quarterback Patrick Mahomes (15) during the second half at GEHA Field at Arrowhead Stadium.
(Jay Biggerstaff, Imagn Images)
8/16
Kansas City Chiefs' playoff chances end with Patrick Mahomes injury
Kansas City Chiefs head coach Andy Reid reacts to a play against the Los Angeles Chargers during the third quarter at GEHA Field at Arrowhead Stadium in Kansas City, Mo. on Dec 14, 2025..
(Denny Medley, Imagn Images)
9/16
Kansas City Chiefs' playoff chances end with Patrick Mahomes injury
Los Angeles Chargers head coach Jim Harbaugh breaks up a confrontation between safety Tony Jefferson (23) and the Kansas City Chiefs during the fourth quarter at GEHA Field at Arrowhead Stadium. Jefferson was subsequently ejected.
(Jay Biggerstaff, Imagn Images)
10/16
Kansas City Chiefs' playoff chances end with Patrick Mahomes injury
Los Angeles Chargers running back Omarion Hampton (8) intercepts a pass intended for Kansas City Chiefs running back Kareem Hunt (29) during the fourth quarter at GEHA Field at Arrowhead Stadium.
(Denny Medley, Imagn Images)
11/16
Kansas City Chiefs' playoff chances end with Patrick Mahomes injury
Los Angeles Chargers cornerback Cam Hart (20) breaks up a pass intended for Kansas City Chiefs wide receiver Tyquan Thornton (80) during the second quarter at GEHA Field at Arrowhead Stadium.
(Denny Medley, Imagn Images)
12/16
Kansas City Chiefs' playoff chances end with Patrick Mahomes injury
Los Angeles Chargers quarterback Justin Herbert (10) passes against the Kansas City Chiefs during the fourth quarter at GEHA Field at Arrowhead Stadium.
(Jay Biggerstaff, Imagn Images)
13/16
Kansas City Chiefs' playoff chances end with Patrick Mahomes injury
Kansas City Chiefs tight end Travis Kelce (87) falls to the ground after being tackled against the Los Angeles Chargers during the second half at GEHA Field at Arrowhead Stadium.
(Jay Biggerstaff, Imagn Images)
14/16
Kansas City Chiefs' playoff chances end with Patrick Mahomes injury
Los Angeles Chargers safety Derwin James Jr. (3) celebrates with cornerback Donte Jackson (26) and linebacker Daiyan Henley (0) following an interception against the Kansas City Chiefs during the fourth quarter at GEHA Field at Arrowhead Stadium.
(Jay Biggerstaff, Imagn Images)
15/16
Kansas City Chiefs' playoff chances end with Patrick Mahomes injury
Kansas City Chiefs head coach Andy Reid, left, and Los Angeles Chargers head coach Jim Harbaugh shake hands following a Chargers victory at GEHA Field at Arrowhead Stadium.
(Jay Biggerstaff, Imagn Images)
16/16
Kansas City Chiefs' playoff chances end with Patrick Mahomes injury
Kansas City Chiefs tight end Travis Kelce (87) talks with Los Angeles Chargers safety Derwin James Jr. (3) following a Chargers victory at GEHA Field at Arrowhead Stadium.
(Jay Biggerstaff, Imagn Images)
Mahomes also added he would "be back stronger than ever" from his injury before thanking Chiefs fans for their support.