White Sox vs Padres Prediction, Picks & Odds for Today's MLB Game

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The Padres have dropped three consecutive games for the first time this season.

With their offense heating up at home, my  White Sox vs. Padres predictions see them getting back in the win column Saturday.

Let’s break down my daily MLB picks for May 2.

Who will win White Sox vs Padres today: Padres moneyline (-190)

The San Diego Padres have feasted on right-handed pitching at home over the past month, hitting .269 with a .814 OPS and .357 wOBA – all Top-7 marks.

They should cause problems for Sean Burke , whose ERA is nearly a full run below his FIP thus far. That’s a red flag.

While Burke has limited quality contact, he doesn’t miss many bats, which could get him into trouble against this lineup.

The Padres did real damage at home in April, finishing fifth in total hits and seventh in homers per at bat.

COVERS INTEL:

Sean Burkes ranks in the 32nd percentile in expected batting average allowed.

White Sox vs Padres Over/Under pick: Over 8.0 (-104)

Burke has done a better job of limiting hard contact but his home run to fly ball rate is only ~62% of his career average, a sign some regression could be coming. 

The Padres rank 10th in HR/FB vs. righties over the last month and eighth at home, making them a real test for Burke.

On the other side, Padres starter Michael King ranks in the 32nd percentile in barrel suppression. The Chicago White Sox sit ninth in homers and fifth in ISO vs. righties on the road so they have the power to capitalize.

Todd Cordell's 2026 Transparency Record

• ML/RL bets:10-3, +6.18 units

• Over/Under bets:6-7, -1.72 units

White Sox vs Padres odds

• Moneyline: Chicago ( +160 ) | San Diego (-190)

• Run line: Chicago +1.5 (-125) | San Diego -1.5 (+105)

• Over/Under: Over 8.0 (-105) | Under 8.0 (-115)

White Sox vs Padres trend

The Chicago White Sox have hit the Game Total Over in 11 of their last 15 away games (+6.55 Units / 39% ROI). Find more  MLB betting trends for White Sox vs. Padres.

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Odds are correct at the time of publishing and are subject to change.
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