Isaac Brown won't be No. 15 Louisville football's only loss when it plays California on Saturday.
The Cardinals may also be without fellow running back Duke Watson , who was listed as probable, according to Thursday night's ACC injury report . Linebacker Stanquan Clark , who has missed most of the season, was listed as questionable.
Louisville 's running back room hasn't been healthy since the beginning of the season — with Isaac Brown , Keyjuan Brown and Watson, who's been out for four games, all suffering injuries.
Though Isaac Brown seemed to have made a full recovery, he went down on Virginia Tech's sideline after being tackled. He walked gingerly off the field with what appeared to be a right hamstring injury. Watson has been out for a month with a right ankle injury. Keyjuan Brown , too, battled a lower leg injury but has recovered. He'll be the Cardinals ' starting running back Saturday, and Braxton Jennings likely will get some reps.
Cornerback Justin Agu will also be out, and offensive lineman Sam Secrest was listed as probable.
Louisville kicks off against Cal at 7 p.m. Saturday at L&N Stadium.
Reach Louisville football , women's basketball and baseball beat writer Alexis Cubit at acubit@gannett.com and follow her on X at @Alexis_Cubit.
This article originally appeared on Louisville Courier Journal: Louisville vs California football injury news for Week 11 ACC game

