Week 10 of the 2025 college football season features 47 games from Thursday, Oct. 30 through Saturday night on Nov. 1. Athlon Sports is back with predictions and picks for every contest.
The 10th full weekend of the '25 season started with James Madison and Kennesaw State picking up victories on Tuesday night. And in Wednesday Conference USA action, Missouri State defeated FIU, while Jacksonville State knocked off Middle Tennessee. The action continues with two contests on Thursday, with Coastal Carolina hosting Marshall and Tulane playing at UTSA. Three contests are slated for Friday, with Memphis-Rice, North Carolina-Syracuse, and Sam Houston-Louisiana Tech headlining the action.
A loaded schedule of games is on tap for Saturday this week. Penn State-Ohio State, Vanderbilt-Texas, Miami-SMU, Duke-Clemson, and Navy-North Texas headline the top contests in the first window. The afternoon slate includes Notre Dame-Boston College, Michigan State-Minnesota, Indiana-Maryland, Texas Tech-Kansas State, Mississippi State-Arkansas, and Florida-Georgia in Jacksonville.
BEST BETS AGAINST THE SPREAD: Our experts' picks for Week 10
The first night window is headlined by South Carolina-Ole Miss, Georgia Tech-NC State, Oklahoma-Tennessee, USC-Nebraska, and Wake Forest-Florida State. The late-night portion of the Week 10 schedule features Cincinnati-Utah and Hawaii-San Jose State.
| * | * | * | * | * |
| * | * | Steven Lassan |
Thomas Neumann |
Kyle Wood |
| Marshall |
@ Coastal Carolina |
Marshall |
Marshall |
Marshall |
| Tulane |
@ UTSA |
Tulane |
UTSA |
Tulane |
| Memphis |
@ Rice |
Memphis |
Memphis |
Memphis |
| North Carolina |
@ Syracuse |
UNC |
Syracuse |
UNC |
| Sam Houston |
@ Louisiana Tech |
LT |
LT |
LT |
| Penn State |
@ Ohio State |
Ohio State |
Ohio State |
Ohio State |
| Indiana |
@ Maryland |
Indiana |
Indiana |
Indiana |
| Georgia Tech |
@ NC State |
GT |
GT |
GT |
| South Carolina |
@ Ole Miss |
Ole Miss |
Ole Miss |
Ole Miss |
| Miami |
@ SMU |
Miami |
Miami |
Miami |
| Notre Dame |
@ Boston College |
ND |
ND |
ND |
| Oklahoma |
@ Tennessee |
Tennessee |
Oklahoma |
Tennessee |
| Texas Tech |
@ Kansas State |
Texas Tech |
Texas Tech |
Texas Tech |
| Virginia |
@ California |
Cal |
Cal |
UVA |
| Louisville |
@ Virginia Tech |
Louisville |
Louisville |
Louisville |
| Cincinnati |
@ Utah |
Utah |
Utah |
Cincinnati |
| Rutgers |
@ Illinois |
Illinois |
Illinois |
Illinois |
| Arizona State |
@ Iowa State |
Iowa State |
Iowa State |
Iowa State |
| Purdue |
@ Michigan |
Michigan |
Michigan |
Michigan |
| Mississippi State |
@ Arkansas |
MSU |
MSU |
MSU |
| Kentucky |
@ Auburn |
Auburn |
Auburn |
Auburn |
| Michigan State |
@ Minnesota |
Minnesota |
MSU |
Minnesota |
| USC |
@ Nebraska |
USC |
USC |
USC |
| Duke |
@ Clemson |
Clemson |
Clemson |
Duke |
| Wake Forest |
@ Florida State |
FSU |
FSU |
FSU |
| Pittsburgh |
@ Stanford |
Pitt |
Pitt |
Pitt |
| UCF |
@ Baylor |
Baylor |
UCF |
Baylor |
| Arizona |
@ Colorado |
Arizona |
Arizona |
Arizona |
| West Virginia |
@ Houston |
Houston |
Houston |
Houston |
| Oklahoma State |
@ Kansas |
Kansas |
Kansas |
Kansas |
| Fresno State |
@ Boise State |
Boise State |
Boise State |
Boise State |
| Old Dominion |
@ UL Monroe |
ODU |
ODU |
ODU |
| Louisiana |
@ South Alabama |
USA |
USA |
USA |
| Arkansas State |
@ Troy |
Troy |
Troy |
Troy |
| East Carolina |
@ Temple |
ECU |
Temple |
Temple |
| Navy |
@ North Texas |
North Texas |
North Texas |
North Texas |
| Buffalo |
@ Bowling Green |
Buffalo |
BGSU |
Buffalo |
| Central Michigan |
@ Western Michigan |
WMU |
WMU |
WMU |
| Vanderbilt |
@ Texas |
Texas |
Vanderbilt |
Vanderbilt |
| UAB |
@ UConn |
UConn |
UConn |
UConn |
| Army |
@ Air Force |
AFA |
AFA |
Army |
| New Mexico |
@ UNLV |
UNLV |
UNLV |
UNLV |
| Georgia |
@ Florida |
Georgia |
Georgia |
Georgia |
| Delaware |
@ Liberty |
Liberty |
Liberty |
Delaware |
| New Mexico State |
@ Western Kentucky |
WKU |
WKU |
WKU |
| Wyoming |
@ San Diego State |
SDSU |
SDSU |
SDSU |
| Washington State |
@ Oregon State |
Wazzu |
Wazzu |
Wazzu |
| Hawai'i |
@ San José State |
Hawaii |
Hawaii |
Hawaii |
| Week 9 |
Record |
40-13 |
41-12 |
37-16 |
| Season |
Record |
462-122 |
461-123 |
457-127 |
Related: College Football Best Bets: ATS Picks for Top-25 Week 10 Games
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This story was originally reported by Athlon Sports on Oct 30, 2025, where it first appeared in the College Football section. Add Athlon Sports as a Preferred Source by clicking here.
