
| Player | Pos | Status | Date |
|---|---|---|---|
| RP | 7-day IL (Undisclosed) | 5/2 | |
| RP | 7-day IL (Undisclosed) | 5/2 | |
| RP | 60-day IL (Elbow) | 5/2 | |
| 1B | 7-day IL (Undisclosed) | 5/2 | |
| SS | 7-day IL (Thumb) | 5/2 | |
| LF | 7-day IL (Undisclosed) | 5/2 | |
| LF | 7-day IL (Hamstring) | 5/2 | |
| RP | 15-day IL (The Baltimore Orioles placed RHP Ryan Helsley on the 15-day injured list with right elbow inflammation.) | 5/1 | |
| SP | 15-day IL (The Baltimore Orioles placed LHP Trevor Rogers on the 15-day injured list due to illness.) | 4/26 | |
| SP | 15-day IL (The Baltimore Orioles placed RHP Dean Kremer on the 15-day injured list due to right quad strain.) | 4/23 | |
| 1B | 60-day IL (The Baltimore Orioles placed INF Ryan Mountcastle on the 60-day injured list.) | 4/11 | |
| RP | 60-day IL (The Baltimore Orioles transferred RHP Yaramil Hiraldo to the 60-day injured list with right shoulder inflammation.) | 4/2 | |
| SP | 60-day IL (The Baltimore Orioles transferred RHP Zach Eflin from the 15-day injured list to the 60-day injured list with right elbow discomfort.) | 4/1 | |
| LF | 10-day IL (The Baltimore Orioles placed OF Heston Kjerstad on the 10-day injured list with right hamstring strain.) | 3/22 | |
| 2B | 10-day IL (The Baltimore Orioles placed INF Jackson Holliday on the 10-day injured list as he recovers from right hamate surgery.) | 3/22 | |
| 3B | 60-day IL (The Baltimore Orioles transferred INF Jordan Westburg from the 10-day injured list to the 60-day injured list with a partially torn UCL in his elbow.) | 2/20 | |
| RP | 60-day IL (The Baltimore Orioles placed RHP Félix Bautista on the 60-day injured list.) | 2/20 | |
| SP | 60-day IL (The Baltimore Orioles placed RHP Colin Selby on the 60-day injured list due to right shoulder inflammation.) | 2/14 |