
| Player | Pos | Status | Date |
|---|---|---|---|
| RP | day-to-day (Forearm) | 9/4 | |
| RP | 7-day IL (Undisclosed) | 9/4 | |
| RP | 60-day IL (Undisclosed) | 9/4 | |
| SP | 15-day IL (The Chicago Cubs placed RHP Edward Cabrera on the 15-day injured list due to a right middle finger blister) | 8/17 | |
| SS | 10-day IL (The Chicago Cubs placed INF Dansby Swanson on the 10-day injured list.) | 8/16 | |
| RP | 15-day IL (The Chicago Cubs placed RHP Gavin Hollowell on the 15-day injured list due to right shoulder inflammation.) | 7/31 | |
| RP | 60-day IL (The Chicago Cubs transferred RHP Phil Maton from the 15-day injured list to the 60-day injured list due to right knee tendinitis.) | 7/20 | |
| RP | 60-day IL (The Chicago Cubs transferred RHP Ben Brown from the 15-day injured list to the 60-day injured list with a neck strain.) | 6/21 | |
| RP | 60-day IL (The Chicago Cubs transferred LHP Riley Martin from the 15-day injured list to the 60-day injured list due to left elbow flexor strain.) | 4/26 | |
| RP | 60-day IL (The Chicago Cubs transferred RHP Hunter Harvey to the 60-day injured list with right triceps inflammation.) | 4/9 | |
| SP | 60-day IL (The Chicago Cubs transferred RHP Cade Horton to the 60-day injured list due right forearm discomfort.) | 4/4 | |
| 1B | 60-day IL (The Chicago Cubs placed INF Tyler Austin on the 60-day injured list due to a right knee injury.) | 3/25 | |
| SP | 60-day IL (The Chicago Cubs placed LHP Justin Steele on the 60-day injured list with a left elbow injury.) | 3/25 | |
| RP | 60-day IL (The Chicago Cubs transaferred RHP Porter Hodge to the 60-day injured list with a right elbow strain.) | 3/22 | |
| RP | 60-day IL (The Chicago Cubs placed RHP Shelby Miller on the 60-day injured list due to a right elbow UCL injury.) | 3/1 |