
| Player | Pos | Status | Date |
|---|---|---|---|
| RP | 60-day IL (Elbow) | 9/4 | |
| RP | 15-day IL (The Chicago White Sox placed RHP Huascar Brazobán on the 15-day injured list due to left lat strain.) | 8/25 | |
| RP | 15-day IL (The Chicago White Sox placed LHP Chris Murphy on the 15-day injured list with a left flexor strain.) | 8/7 | |
| C | 10-day IL (The Chicago White Sox placed C Joey Bart on the 10-day injured list with a fifth metacarpal fracture in his left hand.) | 8/6 | |
| RP | 60-day IL (The Chicago White Sox transferred RHP Jordan Leasure to the 60-day injured list with a right flexor strain.) | 5/29 | |
| LF | 60-day IL (The Chicago White Sox transferred INF Tanner Murray to the 60-day injured list with a left shoulder dislocation and fracture.) | 4/27 | |
| RP | 60-day IL (The Chicago White Sox transferred RHP Mike Vasil from the 15-day injured list to the 60-day injured list as he recovers from Tommy John surgery.) | 3/25 | |
| SP | 60-day IL (The Chicago White Sox transferred RHP Drew Thorpe to the 60-day injured list as he recovers from Tommy John surgery.) | 3/25 | |
| LF | 60-day IL (The Chicago White Sox transferred OF Brooks Baldwin from the 10-day injured list to the 60-day injured list with a right elbow sprain.) | 3/25 | |
| SP | 60-day IL (The Chicago White Sox placed LHP Ky Bush on the 60-day injured list due to elbow problems following his Tommy John surgery.) | 2/10 |