NFC West Showdown: Rams vs. 49ers Game Preview & Picks Tonight’s NFC West clash features the Rams and 49ers, both with strong lineups despite injuries. Key players like Kittle and McCaffrey are set to play. 2:23 Now Playing Paused Ad Playing NFC West Showdown: 49ers vs. Rams Game Analysis & Preview 3:15 Now Playing Paused Ad Playing Rams vs. 49ers: Who's the Top Contender in the NFC West? 1:08 Now Playing Paused Ad Playing 49ers vs. Rams Projected Starting Offenses: Week 1 Lineup Breakdown in Melbourne 2:06 Now Playing Paused Ad Playing What is the 'real issue' for the Rams vs 49ers? 1:50 Now Playing Paused Ad Playing 49ers-Rams preview: Health vs. hype in Australia 3:00 Now Playing Paused Ad Playing Rams vs. 49ers: Who Faces More Pressure in NFL Showdown? 4:59 Now Playing Paused Ad Playing Key health updates ahead of 49ers vs. Rams 3:46 Now Playing Paused Ad Playing San Francisco 49ers Crush LA Rams in Week 1 Matchup 4:39 Now Playing Paused Ad Playing Nick Bosa & George Kittle Set to Return for 49ers vs. Rams 2:24 Now Playing Paused Ad Playing 49ers vs. Rams Projected Starting Defenses: Front Seven Changes and Week 1 Depth 2:28 Now Playing Paused Ad Playing SportsGrid NFC West Showdown: Rams vs. 49ers Game Preview & Picks SportsGrid Thu, Sep 10, 2026 Tonight's NFC West clash features the Rams and 49ers , both with strong lineups despite injuries. Key players like Kittle and McCaffrey are set to play. NFC West Showdown: Rams vs. 49ers Game Preview & Picks Tonight’s NFC West clash features the Rams and 49ers, both with strong lineups despite injuries. Key players like Kittle and McCaffrey are set to play. 2:23 Now Playing Paused Ad Playing NFC West Showdown: 49ers vs. Rams Game Analysis & Preview 3:15 Now Playing Paused Ad Playing Rams vs. 49ers: Who's the Top Contender in the NFC West? 1:08 Now Playing Paused Ad Playing 49ers vs. Rams Projected Starting Offenses: Week 1 Lineup Breakdown in Melbourne 2:06 Now Playing Paused Ad Playing What is the 'real issue' for the Rams vs 49ers? 1:50 Now Playing Paused Ad Playing 49ers-Rams preview: Health vs. hype in Australia 3:00 Now Playing Paused Ad Playing Rams vs. 49ers: Who Faces More Pressure in NFL Showdown? 4:59 Now Playing Paused Ad Playing Key health updates ahead of 49ers vs. Rams 3:46 Now Playing Paused Ad Playing San Francisco 49ers Crush LA Rams in Week 1 Matchup 4:39 Now Playing Paused Ad Playing Nick Bosa & George Kittle Set to Return for 49ers vs. Rams 2:24 Now Playing Paused Ad Playing 49ers vs. Rams Projected Starting Defenses: Front Seven Changes and Week 1 Depth 2:28 Now Playing Paused Ad Playing