NFL Week 5 Predictions: Picks for Every Game, Capped by Bills vs. Rams

Four weeks of the 2026 NFL season are done, and here are picks for every Week 5 game. With Baker Mayfield sidelined, Tampa Bay turns to undrafted rookie Jalen Daniels. The Eagles could be without DeVonta Smith, Saquon Barkley and Lane Johnson in London against a stout Jaguars defense, and Ben Johnson's Bears go to Lambeau Field chasing a big scoring night. The Texans and Titans are still looking for their first win, and the week closes with Josh Allen and Matthew Stafford meeting in a primetime Bills vs. Rams game.