Dr. Ibrahim Elsayed

Dean of Quality Assurance & Institutional EffectivenessProfessor of Pharmaceutical Sciences

Education

• B.Pharm from Cairo University, Egypt in 2004
• MSc in Pharmaceutics and Industrial Pharmacy from Cairo University, Egypt in 2008
• Ph.D. from Cairo University, Egypt in 2011
• Graduate Diploma in Health Profession Education from Gulf Medical University, UAE in 2015

Research Interest

• Use of nanotechnology in drug delivery, solubilization, targeting and bioavailability enhancement

Selected  Publications

• Said, M., Elsayed, I.,Aboelwafa, A. A., Elshafeey, A. H., & Hassan, M. (2024). Ocular Mucoadhesive and Biodegradable Sponge-Like Inserts for the Sustained and Controlled Delivery of Voriconazole; Preparation, D-optimal Factorial Optimization and in-vivo Evaluation. Journal of Pharmaceutical Sciences , 113 (4), 961–973. [ link ]
• Osman, A.L., Hussein, S.E.O., Nizam, I., Dilip, D., Mahamadou, M., Al Herafi, J., Gulroz, S., Elsayed, I.,Eltom, A.E., Finney, D., Kandakurti, P.K. An in Vitro Evaluation of Anti-fungal Activity of Different Nano forms of Fluconazole Against Candida albicans. Biomed Pharmacol J 2023;16(3).
• Adel, S., Fahmy, R. H., Elsayed, I.,Mohamed, M. I., & Ibrahim, R. R. (2023). Fabrication and optimization of itraconazole-loaded zein-based nanoparticles in coated capsules as a promising colon-targeting approach pursuing opportunistic fungal infections.  Drug delivery and translational research ,  13 (12), 2982–3002. [ link ]
• Adel, S., Fahmy, R. H.,  Elsayed, I.,  Mohamed, M. I., & Ragaey Ibrahim, R. (2023). Exploiting Itraconazole-loaded nanomixed micelles in coated capsules as efficient colon-targeted delivery system for improved antifungal and potential anticancer efficacy.  Pharmaceutical Development and Technology , 1–26. [ link ]
• El-Dahmy, R.M.,  Elsayed, I.,  Hussein, J., Althubiti, M., Almaimani, R.A., El-Readi, M.Z., Elbaset, M.A., Ibrahim, B.M.M. Development of Transdermal Oleogel Containing Olmesartan Medoxomil: Statistical Optimization and Pharmacological Evaluation.  Pharmaceutics 2023 ,  15 , 1083. [ link ]
• El-Dahmy, R., Elshafeey, A., Abd El Gawad, N., El-Gazayerly, O. and  Elsayed, I.  2021. Statistical optimization of nanostructured gels for enhancement of vinpocetine transnasal and transdermal permeation.  Journal of Drug Delivery Science and Technology , p.102871. [ link ]
• Algehani, R., Abou Khouzam, R., Hegazy, G., Alamoudi, A., El-Halawany, A., El Dine, R., Ajabnoor, G., Al-Abbasi, F., Baghdadi, M.,  Elsayed, I.,  Hattori, M. and Al-Abd, A.M. 2021. Colossolactone-G synergizes the anticancer properties of 5-fluorouracil and gemcitabine against colorectal cancer cells.  Biomedicine & Pharmacotherapy , 140, p.111730. [ link ]
• Naguib, M.,  Elsayed, I.,  Teaima, M. 2021. Simultaneous Optimization of Oral and Transdermal Nanovesicles for Bioavailability Enhancement of Ivabradine Hydrochloride.  International Journal of Nanomedicine , Volume 16, pp.2917-2931. [ link ]
• Haider, M.,  Elsayed, I., Ahmed, I.S., Fares, A.R. In Situ-Forming Microparticles for Controlled Release of Rivastigmine: In Vitro Optimization and In Vivo Evaluation. Pharmaceuticals. 2021 Jan;14(1):66. [ link ]
• Elsenosy, F.M., Abdelbary, G.A., Elshafeey, A.H.,  Elsayed, I.  and Fares, A.R., 2020. Brain Targeting of Duloxetine HCL via Intranasal Delivery of Loaded Cubosomal Gel: In vitro Characterization, ex vivo Permeation, and in vivo Biodistribution Studies.  International Journal of Nanomedicine ,  15 , pp.9517-9537. [ link ]
• Hussain, Z., Thu, H.,  Elsayed, I. , Abourehab, M., Khan, S., Sohail, M., Sarfraz, R. and Farooq, M., 2020. Nano-scaled materials may induce severe neurotoxicity upon chronic exposure to brain tissues: A critical appraisal and recent updates on predisposing factors, underlying mechanism, and future prospects.  Journal of Controlled Release. [ link ]
• Said, M., Aboelwafa, A., Elshafeey, A., &  Elsayed, I.  (2020). Central Composite Optimization of Ocular Mucoadhesive Cubosomes for Enhanced Bioavailability and Controlled Delivery of Voriconazole.  Journal Of Drug Delivery Science And Technology , 102075. doi: 10.1016/j.jddst.2020.102075. [ link ]
• Joseph Naguib, M., Moustafa Kamel, A., Thabet Negmeldin, A., Elshafeey, A. H., &  Elsayed, I.  (2020). Molecular docking and statistical optimization of taurocholate-stabilized galactose anchored bilosomes for the enhancement of sofosbuvir absorption and hepatic relative targeting efficiency.  Drug Delivery ,  27 (1), 996-1009. [ link ]
• Elshafeey, A., Zayed, R., Shukr, M., &  Elsayed, I.  (2020). Sucrose acetate isobutyrate based nanovesicles: A promising platform for drug delivery and bioavailability enhancement.  Journal Of Drug Delivery Science And Technology , 101806. doi: 10.1016/j.jddst.2020.101806. [ link ]
• Elsayed, I. , El-Dahmy, R.M., El-Emam, S.Z. et al. Response surface optimization of biocompatible elastic nanovesicles loaded with rosuvastatin calcium: enhanced bioavailability and anticancer efficacy.  Drug Deliv. and Transl. Res. (2020). [ link ]
• El-Ridy MS, Yehia SA,  Elsayed I , Younis MM, F. Abdel-Rahman R, El-Gamil MA. (2019) Metformin hydrochloride and wound healing: from nanoformulation to pharmacological evaluation. Journal of liposome research. 23:1-4. – [ link ]
• Elsayed, I. , El-Dahmy, R. M., Elshafeey, A. H., El Gawad, A., Abdelaziz, N., Gazayerly, E., & Naim, O. (2019). Tripling the Bioavailability of Rosuvastatin Calcium Through Development and Optimization of an In-Situ Forming Nanovesicular System.  Pharmaceutics ,  11 (6), 275. [Link]
• El-Ridy, M.S., Yehia S.A., Elsayed, I., Younis, M.M., Fawzy, A.R.R., & Ahmed, E.M. (2018). Metformin hydrochloride and wound healing: from nanoformulation to pharmacological evaluation, Journal of Liposome Research, 1-18 [Link]
• Sayed, S., Elsayed, I., Ismail, M.M. (2018). Optimization of β-cyclodextrin consolidated micellar dispersion for promoting the transcorneal permeation of a practically insoluble drug.  International Journal of Pharmaceutics,  549(1), 249-60. [Link]
• Said, M.,  Elsayed, I. , Aboelwafa, A. A., & Elshafeey, A. H. (2018). A novel concept of overcoming the skin barrier using augmented liquid nanocrystals: Box-Behnken optimization, ex vivo and in vivo evaluation.  Colloids and Surfaces B: Biointerfaces ,  170 (1) , 258-265.  [Link]
• Afify, E. A. M. R.,  Elsayed, I. , Gad, M. K., Mohamed, M. I., & Afify, A. E. M. R. (2018). Enhancement of pharmacokinetic and pharmacological behavior of ocular dorzolamide after factorial optimization of self-assembled nanostructures.  PLoS One ,  13 (2), e0191415 [Link]
• Said, M., Elsayed,I., Aboelwafa, A. A., & Elshafeey, A. H. (2017). Transdermal agomelatine microemulsion gel: pyramidal screening, statistical optimization and in vivo bioavailability. Drug Delivery 24(1), 1159. [Link]
• Abdelrahman, F. E., Elsayed, I., Gad, M. K., Elshafeey, A. H., & Mohamed, M. I. (2017). Response surface optimization, Ex vivo and In vivo investigation of nasal spanlastics for bioavailability enhancement and brain targeting of risperidone. International Journal of Pharmaceutics, 530(1-2), 1. [Link]
• Elsayed, I., & AbouGhaly, M. H. (2016). Inhalable nanocomposite microparticles: preparation, characterization and factors affecting formulation. Expert Opinion in Drug Delivery, 13(2), 207. [Link]
• Abdelrahman, F. E., Elsayed, I., Gad, M. K., Badr, A., & Mohamed, M. I. (2015). Investigating the cubosomal ability for transnasal brain targeting: In vitro optimization, ex vivo permeation and in vivo biodistribution. International Journal of Pharmaceutics, 490(1-2), 281. [Link]
• Mohamed, D., Elsayed, I., Mohamed, A. F., & Yehia, S. A. (2015). Real time stability and viability prediction of the anticancer BCG after lyophilization. Drug Development and Industrial Pharmacy, 41(11), 1769. [Link]
• Ahmed Abdelbary, A., Elsayed, I., & Hassen Elshafeey, A. (2015). Design and development of novel lipid based gastroretentive delivery system: response surface analysis, in-vivo imaging and pharmacokinetic study. Drug Delivery, 22(1), 37. [Link]
• El-Dahmy, R. M., Elsayed, I., Elshafeey, A. H., Gawad, N. A., & El-Gazayerly, O. N. (2014). Optimization of long circulating mixed polymeric micelles containing vinpocetine using simple lattice mixture design, in vitro and in vivo characterization. International Journal of Pharmaceutics, 477(1-2), 39. [Link]
• ElKasabgy, N. A., Elsayed, I., & Elshafeey, A. H. (2014). Design of lipotomes as a novel dual functioning nanocarrier for bioavailability enhancement of lacidipine: in-vitro and in-vivo characterization. International Journal of Pharmaceutics, 472(1-2), 369. [Link]
• Elsayed, I., Abdelbary, A. A., & Elshafeey, A. H. (2014). Nanosizing of a poorly soluble drug: technique optimization, factorial analysis, and pharmacokinetic study in healthy human volunteers. International Journal of Nanomedicine, 9, 2943. [Link]
• Shamma, R. N., & Elsayed, I.(2013). Transfersomal lyophilized gel of buspirone HCl: formulation, evaluation and statistical optimization. Journal of Liposome Research, 23(3), 244. [Link]