Dr. Shery Jacob

Professor of Pharmaceutics

Education

• B.Pharm from Mangalore University, India in 1992
• M.Pharm in Pharmaceutics from Birla Institute of Technology, India in 1997
• Ph.D. in Pharmaceutics from Manipal Academy of Higher Education, India in 2006
• Post-Doctoral Fellowship in bioengineering from Clemson University, South Carolina, USA in 2008.

Research Interest

• Pharmaceutical pre-formulation and material characterization
• Solubility enhancement technologies
• Nanotechnology in drug delivery

Selected  Publications

• Ranch, K., Chawnani, D., Jani, H., Acharya, D., Patel, C. A.,  Jacob, S.,  … Boddu, S. H. S. (2024). An update on the latest strategies in retinal drug delivery. Expert Opinion on Drug Delivery, 1–18. [ link ]
• Jacob, S., Kather, F.S. , Morsy, M.A., Boddu, S.H.S., Attimarad, M., Shah, J., Shinu, P., Nair, A.B. Advances in Nanocarrier Systems for Overcoming Formulation Challenges of Curcumin: Current Insights. Nanomaterials 2024,  14, 672. [ link ]
• Gandhi, S., Shastri, D.H., Shah, J., Nair, A.B., Jacob, S. Nasal Delivery to the Brain: Harnessing Nanoparticles for Effective Drug Transport. Pharmaceutics 2024, 16, 481. [ link ]
• Alfehaid, F.S., Nair, A.B., Shah, H., Aldhubiab, B., Shah, J., Mewada, V., Jacob, S.,Attimarad, M. (2024). Enhanced transdermal delivery of apremilast loaded ethosomes: Optimization, characterization and in vivo evaluation. Journal of Drug Delivery Science and Technology , 91(1) 105211. [ link ]
• Vyas, G., Jigar, S., Jacob, S. Enhancement of Physicochemical and Pharmacokinetic Characteristics of Ranolazine drug substance using Cocrystalization Technique. Research Journal of Pharmacy and Technology. 2024; 17(1):59-6. doi: 10.52711/0974-360X.2024.00010
• Jacob, S., Boddu, S.H.S., Bhandare, R., Ahmad, S.S., Nair, A.B. Orodispersible Films: Current Innovations and Emerging Trends. Pharmaceutics 2023, 15 , 2753. [ link ]
• Alfehaid, F. S., Nair, A. B., Shah, H., Al‐Dhubiab, B. E., Shah, J., Mewada, V., Jacob, S., & Attimarad, M. (2023, November 1). Enhanced transdermal delivery of apremilast loaded ethosomes: Optimization, characterization and in vivo evaluation. Journal of Drug Delivery Science and Technology. [ link ]
• AlMulhim, F. M., Nair, A. B., Aldhubiab, B., Shah, H., Shah, J., Mewada, V., Sreeharsha, N., &  Jacob, S . (2023). Design, Development, Evaluation, and In Vivo Performance of Buccal Films Embedded with Paliperidone-Loaded Nanostructured Lipid Carriers. Pharmaceutics, 15( 11), 2530. [ link ]
• Jacob, S.,  Nair, A. B., Boddu, S. H. S., Abuhijjleh, R. K., Selvaraju, K., Babu, T., Gorain, B., Shah, J., & Morsy, M. A. (2023). The emerging role of lipid nanosystems and nanomicelles in liver diseases. In  European Review for Medical and Pharmacological Sciences (Vol. 27). [ link ]
• Neupane, R., Boddu, S.H.S., Al-Tabakha, M.M.,  Jacob, S.,  Babu, R.J., Tiwari, A.K .  Percutaneous absorption and Skin accumulation of Lorazepam-Diphenhydramine- Haloperidol Carbopol gel in Porcine Ear Skin.  AAPS PharmSciTech 24, 183 (2023). [ link ]
• Vyas, G., Shah, J.,  Jacob, S. DoE implementation for Telmisartan and hydrochlorothiazide drug-drug cocrystal synthesis to enhance physicochemical and pharmacokinetic properties. J Appl Pharm Sci, 2023; 13(09):067–076. [ link ]
• Nair, A.B., Aldhubiab, B., Shah, J.,  Jacob, S ., Attimarad, M., Sreeharsha, N., Venugopala, K.N., Joseph, A., Morsy, M.A. Design, Development, and Evaluation of Constant Voltage Iontophoresis for the Transungual Delivery of Efinaconazole. Pharmaceutics  2 023, 15, 1422. [ link ]
• Alissa, I., Nair, A. B., Aldhubiab, B., Shah, H., Shah, J., Mewada, V., Almuqbil, R. M., &  Jacob, S. (2023). Design, Development, and Evaluation of Treprostinil Embedded Adhesive Transdermal Patch. Pharmaceutics, 15(4), 1226. [ link ]
• Shah, Y.B., Mistry, P.S., Dhameliya, T.M., Ranch, K.M., Boddu, S.H.,  Jacob, S. , Mahalakshmi, B., Renukuntla, J. Tuberculosis: Current Treatment Options and Future Scope. In Tubercular Drug Delivery Systems: Advances in Treatment of Infectious Diseases 2023 Mar 15 (pp. 59-77). Cham: Springer International Publishing. [ link ]
• Alnaim, A.S., Shah, H., Nair, A.B., Mewada, V., Patel, S.,  Jacob, S ., Aldhubiab, B., Morsy, M.A., Almuqbil, R.M., Shinu, P., Shah, J. Qbd-Based Approach to Optimize Niosomal Gel of Levosulpiride for Transdermal Drug Delivery.  Gels 2023 ,  9 , 213.
• Patel, C., Pande, S., Sagathia, V., Ranch, K., Beladiya, J., Boddu, S.H.S.,  Jacob, S.,  Al-Tabakha, M.M., Hassan, N., Shahwan, M. Nanocarriers for the Delivery of Neuroprotective Agents in the Treatment of Ocular Neurodegenerative Diseases.   Pharmaceutics 2023 , 15 , 837.
• Nair, A.B., Chaudhary, S.,  Jacob, S ., Patel, D., Shinu, P., Shah, H., Chaudhary, A., Aldhubiab, B., Almuqbil, R.M., Alnaim, A.S., Alqattan, F., Shah, J. Intranasal Administration of Dolutegravir-Loaded Nanoemulsion-Based In Situ Gel for Enhanced Bioavailability and Direct Brain Targeting.  Gels 2023 ,  9 , 130. [ link ]
• Garapati, C., Boddu, S.H, Jacob, S., Ranch, K.M., Patel, C., Babu, R.J., Tiwari, A.K., Yasin, H. Photodynamic Therapy: A Special Emphasis on Nanocarrier-mediated Delivery of Photosensitizers in Antimicrobial Therapy. Arabian Journal of Chemistry. 2023 Jan 16:104583. https:// doi. Org / 10.1016/ j.arabjc. 2023.104583. [ link ]
• Nair, A.B., Gorain, B., Pandey, M.,  Jacob, S ., Shinu, P., Aldhubiab, B., Almuqbil, R.M., Elsewedy, H.S., Morsy, M.A. Tocotrienol in the Treatment of Topical Wounds: Recent Updates.  Pharmaceutics 2022 ,  1 4 , 2479. [ link ]
• Morsy, M.A., Kandeel, M., Ibrahim, A.R.N., Abdel-Gaber, S.A.,  Jacob, S.,  Venugopala, K.N., Shinu, P., El-Daly, M. Carnosine Potentiates Doxorubicin-Induced Cytotoxicity in Resistant NCI/ADR-RES Cells by Inhibiting P-Glycoprotein—In Silico and In Vitro Evidence. Molecules 2022, 27, 7383. [ link ]
• Shinu, P., Nair, A.B., Kumari, B.,  Jacob, S. , Kumar, M., Tiwari, A., Tiwari, V., Venugopala, K.N., Attimarad, M., Nagaraja, S. Recent Advances and Appropriate use of Niosomes for the Treatment of Skin Cancer. Indian Journal of Pharmaceutical Education and Research, 2022; 56(4):924-937. DOI: 10.5530/ ijper.56.4.170. [ link ]
• Jacob, S.,  Nair, A.B., Morsy, M.A. Dose Conversion Between Animals and Humans: A Practical Solution.  Indian Journal of Pharmaceutical Education and Research, 2022; 56(3):600-607. [ link ]
• Shinu, P., Morsy, M., Nair, A., Mouslem, A., Venugopala, K., Goyal, M., Bansal, M.,  Jacob, S.,  & Deb, P. K. (2022). Novel Therapies for the Treatment of Neuropathic Pain: Potential and Pitfalls. Journal Of Clinical Medicine, 11(11), 3002. doi: 10.3390/jcm11113002. [ link ]
• Nair, A., Chaudhary, S., Shah, H.,  Jacob, S.,  Mewada, V., & Shinu, P. et al. (2022). Intranasal Delivery of Darunavir-Loaded Mucoadhesive In Situ Gel: Experimental Design, In Vitro Evaluation, and Pharmacokinetic Studies.  Gels ,  8 (6), 342. doi: 10.3390/gels8060342. [ link ]
• Sengupta, P., Choudhury, H., Dutta, S.,  Jacob, S.,  Kesharwani, P., & Gorain, B. (2022). Current Strategies in Breast Cancer Therapy: Role of Epigenetics and Nanomedicine.  Particle &Amp; Particle Systems Characterization , 2100276. doi: 10.1002/ppsc.202100276. [ link ]
• Kumar, M., Tiwari, A., Asdaq, S.M.B., Nair, A.B., Bhatt, S., Shinu, P., Al Mouslem, A.K.,  Jacob, S.,  Alamri, A.S., Alsanie, W.F., Alhomrani, M., Tiwari, V., Devi, S., Pathania, A., Sreeharsha, N. (2022). Itraconazole loaded nano-structured lipid carrier for topical ocular delivery: Optimization and evaluation.  Saudi Journal of Biological Sciences.  29, (1) 1-10. [ link ]
• Jacob, S.,  Nair, A., Shah, J., Gupta, S., Boddu, S., & Sreeharsha, N. et al. (2022). Lipid Nanoparticles as a Promising Drug Delivery Carrier for Topical Ocular Therapy; An Overview on Recent Advances.  Pharmaceutics ,  14 (3) , 533. doi: 10.3390/pharmaceutics14030533. [ link ]
• Nair, A., Kumar, S., Dalal, P., Nagpal, C., Dalal, S., & Rao, R., Sreeharsha, N.,  Jacob, S.  (2022). Novel Dermal Delivery Cargos of Clobetasol Propionate: An Update.  Pharmaceutics ,  14 (2), 383. doi: 10.3390/pharmaceutics14020383. [ link ]
• Nair, A.B., Singh, B., Shah, J.,  Jacob, S ., Aldhubiab, B., Sreeharsha, N., Morsy, M.A., Venugopala, K.N., Attimarad, M., Shinu, P. Formulation and Evaluation of Self-Nanoemulsifying Drug Delivery System Derived Tablet Containing Sertraline.  Pharmaceutics  2022 ,  14 , 336. [ link ]
• Kumar, S., Yadav Ravulapalli, S., Kumar Tiwari, S., Gupta, S., Nair, A., &  Jacob, S.  (2021). Effect of sex and food on the pharmacokinetics of different classes of BCS drugs in rats after cassette administration.  International Journal Of Pharmaceutics ,  610 , 121221. doi: 10.1016/j.ijpharm.2021.121221. [ link ]
• Boddu, S., Bhagav, P., Karla, P.,  Jacob, S.,  Adatiya, M., & Dhameliya, T. et al. (2021). Polyamide/Poly(Amino Acid) Polymers for Drug Delivery.  Journal Of Functional Biomaterials ,  12 (4), 58. doi: 10.3390/jfb12040058. [ link ]
• Asdaq, S., Rajan, A., Damodaran, A., Kamath, S., Nair, K., & Zachariah, S., Sahu, R., Fattepur, S., Sreeharsha, N., Nair, A.,  Jacob, S.,  et al. (2021). Identifying Mucormycosis Severity in Indian COVID-19 Patients: A Nano-Based Diagnosis and the Necessity for Critical Therapeutic Intervention.  Antibiotics ,  10 ( 11), 1308. doi: 10.3390/antibiotics10111308. [ link ]
• Bhanderi, M., Shah, J., Gorain, B., Nair, A.,  Jacob, S.,  & Asdaq, S. et al. (2021). Optimized Rivastigmine Nanoparticles Coated with Eudragit for Intranasal Application to Brain Delivery: Evaluation and Nasal Ciliotoxicity Studies.  Materials ,  14 (21), 6291. doi: 10.3390/ma14216291. [ link ]
• Nair, A., Al-Dhubiab, B., Shah, J., Gorain, B.,  Jacob, S.,  & Attimarad, M. et al. (2021). Constant Voltage Iontophoresis Technique to Deliver Terbinafine via Transungual Delivery System: Formulation Optimization Using Box–Behnken Design and In Vitro Evaluation.  Pharmaceutics ,  13 ( 10), 1692. [ link ]
• Dalal, R., Shah, J., Gorain, B., Choudhury, H.,  Jacob, S.,  Mehta, T., Shah, H. and Nair, A., 2021. Development and Optimization of Asenapine Sublingual Film Using QbD Approach.  AAPS PharmSciTech , 22(7). [ link ]
• Jacob, S.,  Nair, A., Boddu, S., Gorain, B., Sreeharsha, N. and Shah, J., 2021. An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems.  Pharmaceutics , 13(8), p.1206. [ link ]
• Satyavert, Gupta, S., Choudhury, H.,  Jacob, S.,  Nair, A., Dhanawat, M., & Munjal, K. (2021). Pharmacokinetics and tissue distribution of hydrazinocurcumin in rats.  Pharmacological Reports . doi: 10.1007/s43440-021-00312-5. [ link ]
• Nair, A.B., Shah, J.,  Jacob, S ., Al-Dhubiab, B.E., Patel, V., Sreeharsha, N., Shinu, P. Development of Mucoadhesive Buccal Film for Rizatriptan: In Vitro and In Vivo Evaluation.  Pharmaceutics  2021 ,  13 , 728. [ link ]
• Chaudhary, S., Nair, A.B., Shah, J. Gorain, B.,  Jacob, S.,  Shah, H., Patel, V. Enhanced Solubility and Bioavailability of Dolutegravir by Solid Dispersion Method:  In Vitro  and  In Vivo  Evaluation—a Potential Approach for HIV Therapy.  AAPS PharmSciTech  22, 127 (2021). [ link ]
• Nair. A.B., Shah. J., Al-Dhubiab. B.E.,  Jacob. S.,  Patel. S.S., Venugopala. K.N., Morsy. M.A., Gupta. S., Attimarad. M., Sreeharsha. N., Shinu. P. Clarithromycin Solid Lipid Nanoparticles for Topical Ocular Therapy: Optimization, Evaluation and In Vivo studies.  Pharmaceutics  2021,  1 3 , 523. [ link ]
• Nair. A.B., Shah. J.,  Jacob. S.,  Al-Dhubiab. B.E., Sreeharsha. N., Morsy. M.A., et al. (2021) Experimental design, formulation and  in vivo  evaluation of a novel topical  in situ gel system to treat ocular infections. PLoS ONE 16(3): e0248857. [ link ]
• Shah. H., Nair. A.B., Shah. J.,  Jacob. S.,  Bharadia. P., Haroun. M. “Proniosomal vesicles as an effective strategy to optimize naproxen transdermal delivery’’.  Journal of Drug Delivery Science and Technology. 2021, 63,102479. [ link ]
• Jacob, S.,  Nair, A.B., Shah, J., Sreeharsha, N., Gupta, S., Shinu, P. Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering, and Wound Management. Pharmaceutics 2021 , 13, 357. [ link ]
• Jacob, S.,  Nair, A.B., Patel, V., Shah, J .  3D Printing Technologies: Recent Development and Emerging Applications in Various Drug Delivery Systems.  AAPS PharmSciTech 21, 220 (2020). [ link ]
• Shehata,T.M., Nair,A.B., Al-Dhubiab,B.E., Shah,J., Jacob,S., Alhaider,I.A., Attimarad, M., Elsewedy,H.S., Ibrahim,M.M. Vesicular emulgel based system for transdermal delivery of insulin: Factorial design and in vivo evaluation.  Applied Sciences (2020). [ link ]
• Jhaveri, M.; Nair, A.B.; Shah, J.;  Jacob, S.;  Patel, V.; Mehta,T.  Improvement of oral bioavailability of carvedilol by liquisolid compact: optimization and pharmacokinetic study .  Drug Delivery and Translational Research. (March 2020). [ Link ]
• Jacob, S ., Nair, A.B. & Shah, J. Emerging role of nanosuspensions in drug delivery systems.  Biomater Res 24,  3 (2020). [Link]
• Nair, A.B.; Shah, J.; Al-Dhubiab, B.E.; Patel, S.S.; Morsy, M.A.; Patel, V.; Chavda, V.;  Jacob, S.;  Sreeharsha, N.; Shinu, P.; Attimarad, M.; Venugopala, K.N. Development of Asialoglycoprotein Receptor-Targeted Nanoparticles for Selective Delivery of Gemcitabine to Hepatocellular Carcinoma.  Molecules (2019),  2 4 , 4566. [Link]
• Nair,  A.B.,  Al-Dhubiab,  B.E.,  Shah,  J.,   Jacob,  S. ,  Vismay,  S.,  Attimarad,  M., SreeHarsha,  N.,  Akrawi,  S.H.,  Shehata,  T.M.,  Mucoadhesive  buccal  film  of  almotriptan  improved  therapeuticdelivery in rabbit model, Saudi Pharmaceutical Journal (2019). [Link]
• Nair, A.B., Shah, J., Aljaeid, B.M., Al‐Dhubiab, B.E.,  Jacob, S. (2019). Gellan Gum‐Based Hydrogel for the Transdermal Delivery of Nebivolol: Optimization and Evaluation .  Polymers, 11 (10), 1699. [Link]
• Jacob S,  Nair AB, Shah J (2019). Revisiting clinical practice in therapeutic drug monitoring of first-generation antiepileptic drugs.  Drugs & Therapy Perspectives . 1-8. [Link]
• Nair, A.B., Gupta, S., Al-Dhubiab, B.E.,  Jacob, S ., Shinu, P., Shah, J., Morsy, M.A., SreeHarsha, N., Attimarad, M., Venugopala, K.N., Akrawi, S.H (2019). Effective Therapeutic Delivery and Bioavailability Enhancement of Pioglitazone Using Drug in Adhesive Transdermal Patch.  Pharmaceutics . 11, 359. [Link]
• Jigar, S., Nair, A. B., Hiral, S.,  Jacob, S., Shehata, T. M., & Morsy, M. A. (2019). Enhancement in antinociceptive and anti-inflammatory effects of tramadol by transdermal proniosome gel.  Asian Journal of Pharmaceutical Sciences . [Link]
• Shah, J., Nair, A.B.,  Jacob, S., Patel,R.K.,Shah,H.,Shehata,T. M.,Morsy, M.A. (2019).  Nanoemulsion Based Vehicle for Effective Ocular Delivery of Moxifloxacin Using Experimental Design and  Pharmacokinetic Study in Rabbits .  Pharmaceutics  2019,  1 1 (5), 230. [Link]
• Jacob, S.,  Nair, A.B., Morsy M.A. (2018).  Dose translation between laboratory animals and human in preclinical and clinical phases of drug development .  Drug Development and Research, 21 October 2018. [Link]
• Jacob, S., Nair, A.B. (2018).  Cyclodextrin complexes: Perspective from drug delivery and formulation .  Drug Development and Research, 79(5), 201-217. [Link]
• Jacob, S., Morsy M.A., Nair, A.B. (2018).  An overview on the insulin preparations and devices .  Indian Journal of Pharmaceutical Education and Research, 52(4), 550-557 [Link]
• Jacob,S. ,Nair,A.B.(2018). An updated overview with simple and practical approach for developing in vitro–in vivo correlation.  Drug Development Research,  1-14 [Link]
• Jacob, S.,& Nair, A. B. (2017). A review on therapeutic drug monitoring of the mTOR class of immunosuppressants: everolimus and sirolimus. Drugs & Therapy Perspectives, 1-12. [Link]
• Jacob, S.,& Nair, A. B. (2016). An updated overview on therapeutic drug monitoring of recent antiepileptic drugs. Drugs in R&D, 1-14. [Link]
• Jacob, S.,Nair, A. B., & Al-Dhubiab, B. E. (2016). Preparation and evaluation of niosome gel containing acyclovir for enhanced dermal deposition. Journal of liposome research, 1-10.
• Jacob, S. & Nair, A. B. (2016). A simple practice guide for dose conversion between animals and human. Journal of Basic and Clinical Pharmacy, 7(2), 27. [Link]
• Jacob, S.,Shirwaikar, A., Anoop, S., Khaled, R., Imtiaz, M., & Nair, A. (2016). Acid neutralization capacity and cost-effectiveness of antacids sold in various retail pharmacies in the United Arab Emirates. Hamdan Medical Journal, 9(2), 137
• Jacob, S.,Tambawel, J., Trooshi, F. M., & Alkhoury, Y. (2013). Consumption pattern of nutritional health drinks and energy drinks among university students in Ajman, UAE. Gulf Medical Journal, 2(1), 22. [Link]
• Nair, A., Jacob, S.,Al-Dhubiab, B., Attimarad, M., & Harsha, S. (2013). Basic considerations in the dermatokinetics of topical formulations. Brazilian Journal of Pharmaceutical Sciences, 49(3), 423. [Link]
• Jacob,S,Gupta, R., Kumria, R., Nair, A. B., & Attimarad, M. (2010). Formulation and evaluation of enteric coated tablets of proton pump inhibitor. Journal of Basic and Clinical Pharmacy, 1(4), 215. [Link]
• Jacob,S.,Nair, A. & Reddy, C.(2009). Delivery of a classical antihypertensive agent through the skin by chemical enhancers and iontophoresis. Skin Research and Technology, 15(2), 187. [Link]
• Jacob, S., Shirwaikar, A., & Nair, A. (2009). Preparation and evaluation of fast-disintegrating effervescent tablets of glibenclamide. Drug Development and Industrial Pharmacy, 35(3), 321. [Link]