The 49ers, who already had questionable depth at the defensive end spot, will be even thinner at that position group for the foreseeable future.

When 49ers defensive lineman Sam Okuayinonu hurt his foot in the final practice before the team flight to Australia, there was hope that he could make a later flight and still play in the opener.

A broken foot sidelined a key piece of the San Francisco 49ers defensive line for the foreseeable future.

San Francisco 49ers have made a significant roster move involving veteran defensive end Sam Okuayinonu after his foot injury ruled him out of their season opener. Okuayinonu has been placed on injured reserve, meaning he will miss at least the first four games of the 2026 season.

49ers defensive end Sam Okuayinonu won't play against the Rams on Thursday and he will miss at least three more games as well.

The San Francisco 49ers’ EDGE rusher room is very thin heading into Week 1. Nick Bosa recently returned to practice at full capacity after recovering from an ACL tear and knee tendinitis, which later followed. Mykel Williams is on the PUP list while recovering from an ACL tear and meniscus damage and will miss at […] The post San Francisco 49ers: Place Rotational Piece on Injured Reserve appeared first on Gridiron Heroics.

The San Francisco 49ers' already thin defensive line depth is being tested before their regular season opener.

The San Francisco 49ers will enter Week 1 without an important piece of their defensive line. Defensive lineman Sam Okuayinonu has been ruled out against the Los Angeles Rams. Okuayinonu, who registered 39 tackles, 23 solo tackles, six tackles for loss, three sacks, and one forced fumble in 15 games, was initially listed as questionable […] The post 49ers Lose Sam Okuayinonu for Week 1 vs. Rams After Foot Injury Downgrade appeared first on Gridiron Heroics.

Defensive lineman Khalid Kareem spent the preseason with the New York Giants, but was waived and was signed to the Atlanta Falcons practice squad.