Detroit Lions Are Betting Underdogs To Buffalo Bills Week 2 Detroit Lions open as betting underdogs against Buffalo Bills in Week 2 road contest. 1:31 Now Playing Paused Ad Playing Ride with Bills as 3.5-point favorites vs. Lions 2:15 Now Playing Paused Ad Playing Detroit Lions Week 2 Preview Against Buffalo Bills 2:14 Now Playing Paused Ad Playing How the Detroit Lions will start the 2026 season 3:35 Now Playing Paused Ad Playing Buffalo Bills Open New Stadium Against the Detroit Lions 4:32 Now Playing Paused Ad Playing Week 2 NFL Preview: Lions vs. Bills High-Octane Matchup 3:37 Now Playing Paused Ad Playing Why Detroit Lions Play Was Frustrating Against Buffalo Bills Week 2 2:16 Now Playing Paused Ad Playing Bills-Lions preview: Will Josh Allen, Buffalo roll in new stadium debut? 2:37 Now Playing Paused Ad Playing Instant Reaction to Detroit Lions 41-31 Loss to Buffalo Bills 1:27 Now Playing Paused Ad Playing High-Stakes NFL Showdown: Detroit vs. Buffalo Preview 5:52 Now Playing Paused Ad Playing Lions vs. Bills could be ‘fireworks’ in Week 2 8:13 Now Playing Paused Ad Playing Detroit Lions Are Betting Underdogs To Buffalo Bills Week 2 Detroit Lions On SI Tue, Sep 15, 2026 Detroit Lions open as betting underdogs against Buffalo Bills in Week 2 road contest. Detroit Lions Are Betting Underdogs To Buffalo Bills Week 2 Detroit Lions open as betting underdogs against Buffalo Bills in Week 2 road contest. 1:31 Now Playing Paused Ad Playing Ride with Bills as 3.5-point favorites vs. Lions 2:15 Now Playing Paused Ad Playing Detroit Lions Week 2 Preview Against Buffalo Bills 2:14 Now Playing Paused Ad Playing How the Detroit Lions will start the 2026 season 3:35 Now Playing Paused Ad Playing Buffalo Bills Open New Stadium Against the Detroit Lions 4:32 Now Playing Paused Ad Playing Week 2 NFL Preview: Lions vs. Bills High-Octane Matchup 3:37 Now Playing Paused Ad Playing Why Detroit Lions Play Was Frustrating Against Buffalo Bills Week 2 2:16 Now Playing Paused Ad Playing Bills-Lions preview: Will Josh Allen, Buffalo roll in new stadium debut? 2:37 Now Playing Paused Ad Playing Instant Reaction to Detroit Lions 41-31 Loss to Buffalo Bills 1:27 Now Playing Paused Ad Playing High-Stakes NFL Showdown: Detroit vs. Buffalo Preview 5:52 Now Playing Paused Ad Playing Lions vs. Bills could be ‘fireworks’ in Week 2 8:13 Now Playing Paused Ad Playing
