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Protagonist Therapeutics, Inc. (PTGX)

145.72 -3.08 (-2.07%)
At close: September 4 at 4:00:00 PM EDT
145.00 -0.72 (-0.49%)
After hours: September 4 at 7:30:03 PM EDT
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Chart Range Bar
Loading chart for PTGX
  • Previous Close 148.80
  • Open 146.47
  • Bid 97.79 x 200
  • Ask 175.12 x 200
  • Day's Range 144.13 - 147.99
  • 52 Week Range 54.50 - 160.81
  • Volume 500,996
  • Avg. Volume 671,550
  • Market Cap (intraday) 9.429B
  • Beta (5Y Monthly) 1.79
  • PE Ratio (TTM) 145.72
  • EPS (TTM) 1.00
  • Earnings Date (est.) Nov 5, 2026
  • Forward Dividend & Yield --
  • Ex-Dividend Date --
  • 1y Target Est 174.69

Protagonist Therapeutics, Inc. operates as a discovery and development company in the United States. It develops Icotyde, a first-in-class investigational targeted oral peptide for the treatment of adults and pediatric patients 12 years of age and older with moderate-to-severe plaque psoriasis; and Rusfertide, a first-in-class investigational injectable mimetic of the natural hormone hepcidin in Phase 3 development for the treatment of the rare blood disorder polycythemia vera. The company is also developing PN-881, a potential best-in-class oral peptide IL-17 antagonist, for the treatment of immune-mediated skin diseases in Phase 1 clinical trials; PN-477 and PN-458, which are development candidates for the treatment of obesity; PN-8047, an orally administered hepcidin functional mimetic small molecule; L-4R alpha antagonist for the treatment of atopic dermatitis and moderate-to-severe asthma; and amylinR-based oral and subcutaneous mono- and poly-agonists for the treatment of obesity. Protagonist Therapeutics, Inc. was incorporated in 2006 and is headquartered in Newark, California.

www.protagonist-inc.com

141

Full Time Employees

December 31

Fiscal Year Ends

Healthcare

Sector

Biotechnology

Industry

Performance Overview

Trailing total returns as of 9/4/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC) .

YTD Return

PTGX
66.84%
S&P 500 (^GSPC)
12.75%

1-Year Return

PTGX
144.50%
S&P 500 (^GSPC)
18.71%

3-Year Return

PTGX
645.75%
S&P 500 (^GSPC)
70.93%

5-Year Return

PTGX
198.12%
S&P 500 (^GSPC)
70.18%

Earnings Trends

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Earnings Per Share

GAAP
Normalized
GAAP
Normalized

Revenue vs. Earnings

Annual
Quarterly
Annual
Quarterly
Q2 FY26
Revenue 213.47M
Earnings 162.85M
Profit Margin 76.28%

Q3

FY25

Q4

FY25

Q1

FY26

Q2

FY26

0
50M
100M
150M
200M
-800.0%
-600.0%
-400.0%
-200.0%
0.0%

Analyst Insights

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Analyst Price Targets

149.00
174.69 Average
145.72 Current
225.00 High

Analyst Recommendations

  • Strong Buy
  • Buy
  • Hold
  • Underperform
  • Sell

Latest Rating

Date 9/1/2026
Analyst Barclays
Rating Action Maintains
Rating Overweight
Price Action Raises
Price Target 153 -> 180

Statistics

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Valuation Measures

Annual
As of 9/3/2026
  • Market Cap

    9.63B

  • Enterprise Value

    8.86B

  • Trailing P/E

    144.54

  • Forward P/E

    36.90

  • PEG Ratio (5yr expected)

    --

  • Price/Sales (ttm)

    35.56

  • Price/Book (mrq)

    11.45

  • Enterprise Value/Revenue

    31.42

  • Enterprise Value/EBITDA

    147.96

Financial Highlights

Profitability and Income Statement

  • Profit Margin

    29.40%

  • Return on Assets (ttm)

    4.55%

  • Return on Equity (ttm)

    10.98%

  • Revenue (ttm)

    281.99M

  • Net Income Avi to Common (ttm)

    82.91M

  • Diluted EPS (ttm)

    1.00

Balance Sheet and Cash Flow

  • Total Cash (mrq)

    782.58M

  • Total Debt/Equity (mrq)

    1.10%

  • Levered Free Cash Flow (ttm)

    96.15M

Compare

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Company Insights

Fair Value

145.72 Current

Dividend Score

0 Low
Sector Avg.
100 High

Hiring Score

0 Low
Sector Avg.
100 High

Insider Sentiment Score

0 Low
Sector Avg.
100 High

Research Reports

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  • Lowering target price to $154.00

    PROTAGONIST THERAPEUTICS INC has an Investment Rating of HOLD; a target price of $154.000000; an Industry Subrating of Medium; a Management Subrating of Medium; a Safety Subrating of High; a Financial Strength Subrating of Medium; a Growth Subrating of Medium; and a Value Subrating of High.

    Rating
    Price Target
  • Lowering target price to $158.00

    PROTAGONIST THERAPEUTICS INC has an Investment Rating of HOLD; a target price of $158.000000; an Industry Subrating of Medium; a Management Subrating of Medium; a Safety Subrating of High; a Financial Strength Subrating of Medium; a Growth Subrating of Medium; and a Value Subrating of High.

    Rating
    Price Target
  • Raising target price to $165.00

    PROTAGONIST THERAPEUTICS INC has an Investment Rating of HOLD; a target price of $165.000000; an Industry Subrating of Medium; a Management Subrating of Medium; a Safety Subrating of High; a Financial Strength Subrating of Medium; a Growth Subrating of Medium; and a Value Subrating of High.

    Rating
    Price Target
  • Raising target price to $156.00

    PROTAGONIST THERAPEUTICS INC has an Investment Rating of HOLD; a target price of $156.000000; an Industry Subrating of Medium; a Management Subrating of Medium; a Safety Subrating of High; a Financial Strength Subrating of Medium; a Growth Subrating of Medium; and a Value Subrating of High.

    Rating
    Price Target

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