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ALPS Medical Breakthroughs ETF (SBIO)

70.15 +1.50 (+2.19%)
As of 2:47:24 PM EDT. Market Open.
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  • Previous Close 68.64
  • Open 69.39
  • Bid 70.09 x 30000
  • Ask 70.16 x 230000
  • Day's Range 69.55 - 70.59
  • 52 Week Range 34.50 - 70.85
  • Volume 29,134
  • Avg. Volume 40,192
  • Net Assets 201.57M
  • NAV 69.01
  • PE Ratio (TTM) --
  • Yield 0.00%
  • YTD Daily Total Return 34.93%
  • Beta (5Y Monthly) 0.97
  • Expense Ratio (net) 0.50%

The fund employs a "passive management" - or indexing - investment approach designed to track the performance of the underlying index. It will normally invest at least 80% of its net assets in securities that comprise the underlying index. The underlying index is comprised of small and mid-cap stocks of biotechnology companies that have one or more drugs in either Phase II or Phase III of the U.S. Food and Drug Administration clinical trials.

ALPS

Fund Family

Health

Fund Category

201.57M

Net Assets

2014-12-30

Inception Date

Performance Overview

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Trailing returns as of 8/21/2026. Category is Health.

YTD Return

SBIO
34.93%
Category
2.39%

1-Year Return

SBIO
100.50%
Category
21.31%

3-Year Return

SBIO
34.16%
Category
6.58%

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Holdings

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Top 10 Holdings (32.27% of Total Assets)

Symbol Company % Assets
Crinetics Pharmaceuticals, Inc. 4.75%
Apogee Therapeutics, Inc. 4.48%
CG Oncology, Inc. 3.39%
Xenon Pharmaceuticals Inc. 3.26%
Dianthus Therapeutics, Inc. 3.15%
Oruka Therapeutics, Inc. 3.14%
Travere Therapeutics, Inc. 2.80%
Definium Therapeutics, Inc. 2.56%
ACADIA Pharmaceuticals Inc. 2.39%
MANE 2.36%

Sector Weightings

Research Reports

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  • Daily – Vickers Top Buyers & Sellers for 08/25/2026

    The Vickers Top Buyers & Sellers is a daily report that identifies the five companies the largest insider purchase transactions based on the dollar value of the transactions as well as the five companies the largest insider sales transactions based on the dollar value of the transactions.

  • Alibaba: HKD 80 Billion Placement to Fund AI; Fair Value Estimate Trimmed by 3%

    Alibaba is the world’s largest online and mobile commerce company as measured by gross merchandise volume. It operates China’s online marketplaces, including Taobao (consumer-to-consumer) and Tmall (business-to-consumer). The China retail e-commerce platform is the most valuable cash flow-generating business at Alibaba. Additional revenue sources include China wholesale e-commerce, international retail and wholesale e-commerce, local consumer services, travel services, cloud computing, digital media and entertainment, Cainiao logistics services, and other businesses.

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  • Alibaba Earnings: Free Cash Flow Disappointing Due to High AI Investment; Cut Fair Value by 11%

    Alibaba is the world’s largest online and mobile commerce company as measured by gross merchandise volume. It operates China’s online marketplaces, including Taobao (consumer-to-consumer) and Tmall (business-to-consumer). The China retail e-commerce platform is the most valuable cash flow-generating business at Alibaba. Additional revenue sources include China wholesale e-commerce, international retail and wholesale e-commerce, local consumer services, travel services, cloud computing, digital media and entertainment, Cainiao logistics services, and other businesses.

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    Price Target
  • Tencent Leverages Unrivaled Network Effects to Fuel Growth on Multiple Fronts

    Tencent is the world’s largest game publisher, with top‑grossing mobile hits like Honor of Kings and Peacekeeper Elite and a steady pipeline of new titles. It also operates WeChat—China’s super‑app with roughly 1.3 billion users—embedded in daily life for messaging, short video, mini programs, payments, and shopping. Beyond its own platforms, Tencent is a prolific strategic investor, holding stakes in leading internet companies such as PDD, Kuaishou, and Xiaohongshu.

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