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Alnylam Pharmaceuticals, Inc. (ALNY)

296.11 -13.38 (-4.32%)
At close: May 1 at 4:00:01 PM EDT
303.66 +7.55 (+2.55%)
After hours: May 1 at 7:47:23 PM EDT
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Chart Range Bar
Loading chart for ALNY
  • Previous Close 309.49
  • Open 308.85
  • Bid 295.76 x 200
  • Ask 296.36 x 100
  • Day's Range 295.79 - 311.88
  • 52 Week Range 245.96 - 495.55
  • Volume 1,115,819
  • Avg. Volume 1,236,165
  • Market Cap (intraday) 39.514B
  • Beta (5Y Monthly) --
  • PE Ratio (TTM) 74.59
  • EPS (TTM) 3.97
  • Earnings Date (est.) Jul 30, 2026
  • Forward Dividend & Yield --
  • Ex-Dividend Date --
  • 1y Target Est 449.48

Alnylam Pharmaceuticals, Inc. discovers, develops, manufactures, and commercializes therapeutics based on ribonucleic acid interference in the United States, Europe, and internationally. The company offers ONPATTRO for hereditary transthyretin-mediated (hATTR) amyloidosis; AMVUTTRA for ATTR and hATTR amyloidosis; Leqvio for hypercholesterolemia; Qfitlia for hemophilia A or B; GIVLAARI for acute hepatic porphyria; and OXLUMO for primary hyperoxaluria type 1. It also develops a range of products in Phase 3 trial, such as Nucresiran for ATTR amyloidosis; Zilebesiran for hypertension; Cemdisiran for myasthenia gravis, paroxysmal nocturnal hemoglobinuria, and geographic atrophy; and Elebsiran for hepatitis D virus infections. In addition, the company is developing various products in Phase 2 trial, including Rapirosiran for metabolic dysfunction-associated steatohepatitis; ALN-ANG3 for diabetic kidney disease; ALN-4324 for type 2 diabetes mellitus; Mivelsiran for cerebral amyloid angiopathy, as well as in Phase 1 trial for Alzheimer's disease; and ALN-6400 for bleeding disorders. Further, it develops a range of products in Phase 1 trial, such as ALN-2232 for obesity and weight management; ALN-PNP for non-alcoholic fatty liver disease; ALN-APOC3 for dyslipidemia; ALN-CIDEB for metabolic dysfunction-associated steatohepatitis; ALN-HTT02 for Huntington's disease; ALN-5288 for Alzheimer's disease; ALN-SOD for SOD1 amyotrophic lateral sclerosis; ALN-SNCA for Parkinson's disease; AG-236 for polycythemia vera; ALN-CFB for paroxysmal nocturnal hemoglobinuria; ALN-BCAT for hepatocellular carcinoma; and ALN-4285, ALN-4915, and ALN-F1202 for healthy volunteers. The company has collaborations with Regeneron Pharmaceuticals, Inc.; Roche Holding AG; Sanofi S.A.; Novartis AG; PeptiDream, Inc; Dicerna Pharmaceuticals, Inc.; and Ionis Pharmaceuticals, Inc. Alnylam Pharmaceuticals, Inc. was founded in 2002 and is headquartered in Cambridge, Massachusetts.

www.alnylam.com

2,500

Full Time Employees

December 31

Fiscal Year Ends

Healthcare

Sector

Biotechnology

Industry

Performance Overview: ALNY

Trailing total returns as of 5/1/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC) .

YTD Return

ALNY
25.54%
S&P 500 (^GSPC)
5.62%

1-Year Return

ALNY
16.06%
S&P 500 (^GSPC)
29.01%

3-Year Return

ALNY
46.68%
S&P 500 (^GSPC)
73.47%

5-Year Return

ALNY
110.54%
S&P 500 (^GSPC)
72.92%

Earnings Trends: ALNY

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Earnings Per Share

GAAP
Normalized
GAAP
Normalized

Revenue vs. Earnings

Annual
Quarterly
Annual
Quarterly
Q1 FY26
Revenue 1.17B
Earnings 273.04M

Q2

FY25

Q3

FY25

Q4

FY25

Q1

FY26

0
200M
400M
600M
800M
1B
1B

Analyst Insights: ALNY

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Analyst Price Targets

310.00
449.48 Average
296.11 Current
566.00 High

Analyst Recommendations

  • Strong Buy
  • Buy
  • Hold
  • Underperform
  • Sell

Latest Rating

Date 5/1/2026
Analyst RBC Capital
Rating Action Maintains
Rating Outperform
Price Action Lowers
Price Target 450 -> 445

Statistics: ALNY

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Valuation Measures

Annual
As of 5/1/2026
  • Market Cap

    39.51B

  • Enterprise Value

    37.78B

  • Trailing P/E

    74.40

  • Forward P/E

    33.11

  • PEG Ratio (5yr expected)

    0.59

  • Price/Sales (ttm)

    9.45

  • Price/Book (mrq)

    36.74

  • Enterprise Value/Revenue

    8.81

  • Enterprise Value/EBITDA

    43.64

Financial Highlights

Profitability and Income Statement

  • Profit Margin

    12.55%

  • Return on Assets (ttm)

    10.06%

  • Return on Equity (ttm)

    90.36%

  • Revenue (ttm)

    4.29B

  • Net Income Avi to Common (ttm)

    537.99M

  • Diluted EPS (ttm)

    3.97

Balance Sheet and Cash Flow

  • Total Cash (mrq)

    3.01B

  • Total Debt/Equity (mrq)

    276.20%

  • Levered Free Cash Flow (ttm)

    191.27M

Compare To: ALNY

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Company Insights: ALNY

Fair Value

296.11 Current

Dividend Score

0 Low
Sector Avg.
100 High

Hiring Score

0 Low
Sector Avg.
100 High

Insider Sentiment Score

0 Low
Sector Avg.
100 High

Research Reports: ALNY

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  • Alnylam Earnings: Amvuttra Uptake Drives Sales; Durability of Demand in Focus Amid Competition

    Alnylam Pharmaceuticals is a leader in the study of RNA interference (RNAi) therapeutics. RNAi is a naturally occurring biological pathway within cells for sequence-specific silencing and regulation of gene expression. Alnylam’s commercial RNAi therapeutic products include Onpattro and Amvuttra (for hATTR amyloidosis), Givlaari (for acute hepatic porphyria), and Oxlumo (for primary hyperoxaluria type 1), all developed and commercialized by Alnylam. Plus, Leqvio (for hypercholesterolemia) and Qfitlia (for hemophilia A or B), which are being commercialized by Alnylam’s partners, Novartis and Sanofi, respectively. It also has several clinical programs across various therapeutic areas, including cardio-metabolic diseases, neuroscience, and hematology.

    Rating
    Price Target
  • Narrow-Moat Alnylam's Growth Driven By Strong Demand For Amvuttra in ATTR-CM

    Alnylam Pharmaceuticals is a leader in the study of RNA interference (RNAi) therapeutics. RNAi is a naturally occurring biological pathway within cells for sequence-specific silencing and regulation of gene expression. Alnylam’s commercial RNAi therapeutic products include Onpattro and Amvuttra (for hATTR amyloidosis), Givlaari (for acute hepatic porphyria), and Oxlumo (for primary hyperoxaluria type 1), all developed and commercialized by Alnylam. Plus, Leqvio (for hypercholesterolemia) and Qfitlia (for hemophilia A or B), which are being commercialized by Alnylam’s partners, Novartis and Sanofi, respectively. It also has several clinical programs across various therapeutic areas, including cardio-metabolic diseases, neuroscience, and hematology.

    Rating
    Price Target
  • Daily – Vickers Top Buyers & Sellers for 02/18/2026

    The Vickers Top Buyers & Sellers is a daily report that identifies the five companies the largest insider purchase transactions based on the dollar value of the transactions as well as the five companies the largest insider sales transactions based on the dollar value of the transactions.

  • Alnylam Earnings: Milestone Year as Firm Turned Profitable; Demand for Amvuttra Drives Growth

    Alnylam Pharmaceuticals is a leader in the study of RNA interference (RNAi) therapeutics. RNAi is a naturally occurring biological pathway within cells for sequence-specific silencing and regulation of gene expression. Alnylam has five drugs on the market: Onpattro and Amvuttra for hATTR amyloidosis, Givlaari for acute hepatic porphyria, Oxlumo for primary hyperoxaluria type 1, and Leqvio for hypercholesterolemia. It also has several clinical programs across various therapeutic areas: genetic medicines; cardio-metabolic diseases; hepatic infectious diseases, and CNS/ocular diseases. Upfront fees from research partnerships have boosted Alnylam's cash levels, and the company stands to see additional milestones and royalties from drugs commercialized under collaboration partnerships.

    Rating
    Price Target

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