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CRISPR Therapeutics AG (CRSP)

51.63 -0.71 (-1.36%)
At close: May 1 at 4:00:01 PM EDT
51.42 -0.21 (-0.41%)
After hours: May 1 at 7:59:12 PM EDT
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News headlines CRISPR Therapeutics (CRSP) is facing volatility as analysts expect a $1.14 loss per shareand $8.39 millionin revenue for Q1 2026. Despite early success with its gene therapy Casgevy, the stock has dipped 10%recently due to broader market concerns and mixed earnings expectations.

CRISPR Therapeutics (CRSP) is facing volatility as analysts expect a $1.14 loss per shareand $8.39 millionin revenue for Q1 2026. Despite early success with its gene therapy Casgevy, the stock has dipped 10%recently due to broader market concerns and mixed earnings expectations.

Updated 8m ago · Powered by Yahoo Scout
  • Previous Close 52.34
  • Open 51.59
  • Bid 37.08 x 100
  • Ask 65.95 x 100
  • Day's Range 50.60 - 52.55
  • 52 Week Range 33.03 - 78.48
  • Volume 1,034,560
  • Avg. Volume 1,902,085
  • Market Cap (intraday) 4.979B
  • Beta (5Y Monthly) 1.79
  • PE Ratio (TTM) --
  • EPS (TTM) -6.47
  • Earnings Date (est.) May 11, 2026
  • Forward Dividend & Yield --
  • Ex-Dividend Date --
  • 1y Target Est 83.35

CRISPR Therapeutics AG, a gene editing company, focuses on developing gene-based medicines for serious human diseases using its Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) platform. The company's CRISPR/Cas9 is a technology for gene editing which is the process of precisely altering specific sequences of genomic DNA. It has a portfolio of therapeutic programs across a range of disease areas, including hemoglobinopathies, CAR T cell therapies, in vivo, and type 1 diabetes, as well as develops investigational CAR T programs, including an autologous, gene-edited CAR T program targeting allogeneic chimeric antigen receptor T cell for autoimmune indications and oncology. The company's lead product candidate is CASGEVY, an ex vivo CRISPR/Cas9 gene-edited cell therapy for treating patients suffering from transfusion-dependent beta-thalassemia, severe sickle cell disease (SCD), and hemoglobinopathies in which a patient's hematopoietic stem and progenitor cells are edited to produce high levels of fetal hemoglobin in red blood cells. It also develops CAR T cell therapies, including CTX112 targeting cluster of differentiation 19 (CD19) and CTX131 targeting CD70 for oncology and autoimmune indications; CTX310 and CTX320, in vivo gene editing to address the cardiovascular disease by disrupting the validated targets angiopoietin-like protein 3 and lipoprotein; and CTX211, an allogeneic, gene-edited, hypoimmune stem cell-derived product candidate for the treatment of T1D. It has strategic partnerships with Vertex Pharmaceuticals Incorporated. CRISPR Therapeutics AG was incorporated in 2013 and is headquartered in Zug, Switzerland.

www.crisprtx.com

--

Full Time Employees

December 31

Fiscal Year Ends

Healthcare

Sector

Biotechnology

Industry

Performance Overview: CRSP

Trailing total returns as of 5/1/2026, which may include dividends or other distributions. Benchmark is S&P 500 (^GSPC) .

YTD Return

CRSP
1.54%
S&P 500 (^GSPC)
5.62%

1-Year Return

CRSP
36.84%
S&P 500 (^GSPC)
29.01%

3-Year Return

CRSP
5.20%
S&P 500 (^GSPC)
73.47%

5-Year Return

CRSP
60.67%
S&P 500 (^GSPC)
72.92%

Earnings Trends: CRSP

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Earnings Per Share

GAAP
Normalized
GAAP
Normalized

Revenue vs. Earnings

Annual
Quarterly
Annual
Quarterly
Q4 FY25
Revenue 864k
Earnings -130.61M

Q1

FY25

Q2

FY25

Q3

FY25

Q4

FY25

-100M
-50M
0

Analyst Insights: CRSP

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Analyst Price Targets

33.00
83.35 Average
51.63 Current
291.00 High

Analyst Recommendations

  • Strong Buy
  • Buy
  • Hold
  • Underperform
  • Sell

Latest Rating

Date 3/17/2026
Analyst Piper Sandler
Rating Action Reiterates
Rating Overweight
Price Action Raises
Price Target 105 -> 110

Statistics: CRSP

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Valuation Measures

Annual
As of 5/1/2026
  • Market Cap

    4.98B

  • Enterprise Value

    3.21B

  • Trailing P/E

    --

  • Forward P/E

    --

  • PEG Ratio (5yr expected)

    --

  • Price/Sales (ttm)

    122.27

  • Price/Book (mrq)

    2.59

  • Enterprise Value/Revenue

    84.52

  • Enterprise Value/EBITDA

    --

Financial Highlights

Profitability and Income Statement

  • Profit Margin

    0.00%

  • Return on Assets (ttm)

    -15.76%

  • Return on Equity (ttm)

    -30.18%

  • Revenue (ttm)

    3.51M

  • Net Income Avi to Common (ttm)

    -581.6M

  • Diluted EPS (ttm)

    -6.47

Balance Sheet and Cash Flow

  • Total Cash (mrq)

    1.98B

  • Total Debt/Equity (mrq)

    10.76%

  • Levered Free Cash Flow (ttm)

    -205.62M

Compare To: CRSP

Select to analyze similar companies using key performance metrics; select up to 4 stocks.

Company Insights: CRSP

Fair Value

51.63 Current

Dividend Score

0 Low
Sector Avg.
100 High

Hiring Score

0 Low
Sector Avg.
100 High

Insider Sentiment Score

0 Low
Sector Avg.
100 High

Research Reports: CRSP

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  • Positive Long-Term Outlook for Crispr Therapeutics as Gene Editing Portfolio Makes Progress

    Crispr Therapeutics is a gene editing company focused on the development of Crispr/Cas9-based therapeutics. Crispr/Cas9 stands for clustered regularly interspaced short palindromic repeats (Crispr)/Crispr-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. The company is focused on using this technology to treat genetically defined diseases. Crispr's first approved drug is Casgevy, which was developed in collaboration with Vertex Pharmaceuticals and targets sickle-cell disease and transfusion-dependent beta-thalassemia. The company is advancing a variety of gene editing programs in immuno-oncology, cardiovascular, and a stem cell-derived therapy to treat Type 1 diabetes.

    Rating
    Price Target
  • Positive Long-Term Outlook for Crispr Therapeutics as Gene Editing Portfolio Makes Progress

    Crispr Therapeutics is a gene editing company focused on the development of Crispr/Cas9-based therapeutics. Crispr/Cas9 stands for clustered regularly interspaced short palindromic repeats (Crispr)/Crispr-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. The company is focused on using this technology to treat genetically defined diseases. Crispr's first approved drug is Casgevy, which was developed in collaboration with Vertex Pharmaceuticals and targets sickle-cell disease and transfusion-dependent beta-thalassemia. The company is advancing a variety of gene editing programs in immuno-oncology, cardiovascular, and a stem cell-derived therapy to treat Type 1 diabetes.

    Rating
    Price Target
  • Crispr Earnings: Casgevy Sees Stronger Uptake as Early-Stage Pipeline Assets Make Progress

    Crispr Therapeutics is a gene editing company focused on the development of Crispr/Cas9-based therapeutics. Crispr/Cas9 stands for clustered regularly interspaced short palindromic repeats (Crispr)/Crispr-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. The company is focused on using this technology to treat genetically defined diseases. Crispr's first approved drug is Casgevy, which was developed in collaboration with Vertex Pharmaceuticals and targets sickle-cell disease and transfusion-dependent beta-thalassemia, which have high unmet medical needs. The company is advancing a variety of gene editing programs in immuno-oncology, cardiovascular, and a stem cell-derived therapy to treat Type 1 diabetes.

    Rating
    Price Target
  • Crispr Earnings: Casgevy Sees Stronger Uptake as Early-Stage Pipeline Assets Make Progress

    Crispr Therapeutics is a gene editing company focused on the development of Crispr/Cas9-based therapeutics. Crispr/Cas9 stands for clustered regularly interspaced short palindromic repeats (Crispr)/Crispr-associated protein 9 (Cas9), which is a revolutionary technology for precisely altering specific sequences of genomic DNA. The company is focused on using this technology to treat genetically defined diseases. Crispr's first approved drug is Casgevy, which was developed in collaboration with Vertex Pharmaceuticals and targets sickle-cell disease and transfusion-dependent beta-thalassemia, which have high unmet medical needs. The company is advancing a variety of gene editing programs in immuno-oncology, cardiovascular, and a stem cell-derived therapy to treat Type 1 diabetes.

    Rating
    Price Target

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